Cargando…
Cardio-Ankle Vascular Index and Heart Failure Hospitalization in Patients With Aortic Stenosis Following Transcatheter Aortic Valve Implantation
Background: The cardio-ankle vascular index (CAVI) is associated with the severity of vascular stiffness and heart failure (HF). However, little is known about CAVI in aortic stenosis (AS) patients, probably because of the difficulty of accurately measuring CAVI in these patients owing to their slow...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Circulation Society
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811227/ https://www.ncbi.nlm.nih.gov/pubmed/35178485 http://dx.doi.org/10.1253/circrep.CR-22-0004 |
_version_ | 1784644388378378240 |
---|---|
author | Sobajima, Mitsuo Imamura, Teruhiko Ueno, Yohei Onoda, Hiroshi Tanaka, Shuhei Ushijima, Ryuichi Fukuda, Nobuyuki Ueno, Hiroshi Kinugawa, Koichiro |
author_facet | Sobajima, Mitsuo Imamura, Teruhiko Ueno, Yohei Onoda, Hiroshi Tanaka, Shuhei Ushijima, Ryuichi Fukuda, Nobuyuki Ueno, Hiroshi Kinugawa, Koichiro |
author_sort | Sobajima, Mitsuo |
collection | PubMed |
description | Background: The cardio-ankle vascular index (CAVI) is associated with the severity of vascular stiffness and heart failure (HF). However, little is known about CAVI in aortic stenosis (AS) patients, probably because of the difficulty of accurately measuring CAVI in these patients owing to their slow-rising pulse. In this study, we investigated the prevalence and prognostic impact of abnormally elevated CAVI measured after transcatheter aortic valve implantation (TAVI). Methods and Results: Among patients with AS who underwent TAVI, those with bilateral peripheral artery disease, atrial fibrillation, and systolic HF were excluded. The effect of post-TAVI elevated CAVI (defined as ≥9.0) on HF readmission after the index discharge was investigated. In all, 149 patients (mean [±SD] age 84.8±5.6 years, 24.2% men, mean [±SD] post-TAVI CAVI 9.6±1.4) were included in the study. There was no significant difference in baseline characteristics between groups with and without elevated CAVI, except for lower high-density lipoprotein cholesterol (HDL-C) and a higher prevalence of HF history in the group with elevated CAVI (P<0.05 for both). Post-TAVI elevated CAVI (n=102) was associated with lower freedom from HF recurrence during the observational period (89.1% vs. 100%; median 726 days [interquartile range 329–1,104 days]; P<0.05). Moreover, CAVI was an independent predictor of HF occurrence (hazard ratio 1.62; 95% confidence interval 1.07–2.46; P=0.022). Conclusions: Elevated CAVI was associated with HF occurrence before and after TAVI. |
format | Online Article Text |
id | pubmed-8811227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Circulation Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-88112272022-02-16 Cardio-Ankle Vascular Index and Heart Failure Hospitalization in Patients With Aortic Stenosis Following Transcatheter Aortic Valve Implantation Sobajima, Mitsuo Imamura, Teruhiko Ueno, Yohei Onoda, Hiroshi Tanaka, Shuhei Ushijima, Ryuichi Fukuda, Nobuyuki Ueno, Hiroshi Kinugawa, Koichiro Circ Rep Original article Background: The cardio-ankle vascular index (CAVI) is associated with the severity of vascular stiffness and heart failure (HF). However, little is known about CAVI in aortic stenosis (AS) patients, probably because of the difficulty of accurately measuring CAVI in these patients owing to their slow-rising pulse. In this study, we investigated the prevalence and prognostic impact of abnormally elevated CAVI measured after transcatheter aortic valve implantation (TAVI). Methods and Results: Among patients with AS who underwent TAVI, those with bilateral peripheral artery disease, atrial fibrillation, and systolic HF were excluded. The effect of post-TAVI elevated CAVI (defined as ≥9.0) on HF readmission after the index discharge was investigated. In all, 149 patients (mean [±SD] age 84.8±5.6 years, 24.2% men, mean [±SD] post-TAVI CAVI 9.6±1.4) were included in the study. There was no significant difference in baseline characteristics between groups with and without elevated CAVI, except for lower high-density lipoprotein cholesterol (HDL-C) and a higher prevalence of HF history in the group with elevated CAVI (P<0.05 for both). Post-TAVI elevated CAVI (n=102) was associated with lower freedom from HF recurrence during the observational period (89.1% vs. 100%; median 726 days [interquartile range 329–1,104 days]; P<0.05). Moreover, CAVI was an independent predictor of HF occurrence (hazard ratio 1.62; 95% confidence interval 1.07–2.46; P=0.022). Conclusions: Elevated CAVI was associated with HF occurrence before and after TAVI. The Japanese Circulation Society 2022-01-29 /pmc/articles/PMC8811227/ /pubmed/35178485 http://dx.doi.org/10.1253/circrep.CR-22-0004 Text en Copyright © 2022, THE JAPANESE CIRCULATION SOCIETY https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. |
spellingShingle | Original article Sobajima, Mitsuo Imamura, Teruhiko Ueno, Yohei Onoda, Hiroshi Tanaka, Shuhei Ushijima, Ryuichi Fukuda, Nobuyuki Ueno, Hiroshi Kinugawa, Koichiro Cardio-Ankle Vascular Index and Heart Failure Hospitalization in Patients With Aortic Stenosis Following Transcatheter Aortic Valve Implantation |
title | Cardio-Ankle Vascular Index and Heart Failure Hospitalization in Patients With Aortic Stenosis Following Transcatheter Aortic Valve Implantation |
title_full | Cardio-Ankle Vascular Index and Heart Failure Hospitalization in Patients With Aortic Stenosis Following Transcatheter Aortic Valve Implantation |
title_fullStr | Cardio-Ankle Vascular Index and Heart Failure Hospitalization in Patients With Aortic Stenosis Following Transcatheter Aortic Valve Implantation |
title_full_unstemmed | Cardio-Ankle Vascular Index and Heart Failure Hospitalization in Patients With Aortic Stenosis Following Transcatheter Aortic Valve Implantation |
title_short | Cardio-Ankle Vascular Index and Heart Failure Hospitalization in Patients With Aortic Stenosis Following Transcatheter Aortic Valve Implantation |
title_sort | cardio-ankle vascular index and heart failure hospitalization in patients with aortic stenosis following transcatheter aortic valve implantation |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811227/ https://www.ncbi.nlm.nih.gov/pubmed/35178485 http://dx.doi.org/10.1253/circrep.CR-22-0004 |
work_keys_str_mv | AT sobajimamitsuo cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation AT imamurateruhiko cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation AT uenoyohei cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation AT onodahiroshi cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation AT tanakashuhei cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation AT ushijimaryuichi cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation AT fukudanobuyuki cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation AT uenohiroshi cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation AT kinugawakoichiro cardioanklevascularindexandheartfailurehospitalizationinpatientswithaorticstenosisfollowingtranscatheteraorticvalveimplantation |