Cargando…

Translational Informatics for Natural Products as Antidepressant Agents

Depression, a neurological disorder, is a universally common and debilitating illness where social and economic issues could also become one of its etiologic factors. From a global perspective, it is the fourth leading cause of long-term disability in human beings. For centuries, natural products ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Singla, Rajeev K., Joon, Shikha, Shen, Li, Shen, Bairong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811306/
https://www.ncbi.nlm.nih.gov/pubmed/35127696
http://dx.doi.org/10.3389/fcell.2021.738838
_version_ 1784644403484164096
author Singla, Rajeev K.
Joon, Shikha
Shen, Li
Shen, Bairong
author_facet Singla, Rajeev K.
Joon, Shikha
Shen, Li
Shen, Bairong
author_sort Singla, Rajeev K.
collection PubMed
description Depression, a neurological disorder, is a universally common and debilitating illness where social and economic issues could also become one of its etiologic factors. From a global perspective, it is the fourth leading cause of long-term disability in human beings. For centuries, natural products have proven their true potential to combat various diseases and disorders, including depression and its associated ailments. Translational informatics applies informatics models at molecular, imaging, individual, and population levels to promote the translation of basic research to clinical applications. The present review summarizes natural-antidepressant-based translational informatics studies and addresses challenges and opportunities for future research in the field.
format Online
Article
Text
id pubmed-8811306
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88113062022-02-04 Translational Informatics for Natural Products as Antidepressant Agents Singla, Rajeev K. Joon, Shikha Shen, Li Shen, Bairong Front Cell Dev Biol Cell and Developmental Biology Depression, a neurological disorder, is a universally common and debilitating illness where social and economic issues could also become one of its etiologic factors. From a global perspective, it is the fourth leading cause of long-term disability in human beings. For centuries, natural products have proven their true potential to combat various diseases and disorders, including depression and its associated ailments. Translational informatics applies informatics models at molecular, imaging, individual, and population levels to promote the translation of basic research to clinical applications. The present review summarizes natural-antidepressant-based translational informatics studies and addresses challenges and opportunities for future research in the field. Frontiers Media S.A. 2022-01-20 /pmc/articles/PMC8811306/ /pubmed/35127696 http://dx.doi.org/10.3389/fcell.2021.738838 Text en Copyright © 2022 Singla, Joon, Shen and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Singla, Rajeev K.
Joon, Shikha
Shen, Li
Shen, Bairong
Translational Informatics for Natural Products as Antidepressant Agents
title Translational Informatics for Natural Products as Antidepressant Agents
title_full Translational Informatics for Natural Products as Antidepressant Agents
title_fullStr Translational Informatics for Natural Products as Antidepressant Agents
title_full_unstemmed Translational Informatics for Natural Products as Antidepressant Agents
title_short Translational Informatics for Natural Products as Antidepressant Agents
title_sort translational informatics for natural products as antidepressant agents
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811306/
https://www.ncbi.nlm.nih.gov/pubmed/35127696
http://dx.doi.org/10.3389/fcell.2021.738838
work_keys_str_mv AT singlarajeevk translationalinformaticsfornaturalproductsasantidepressantagents
AT joonshikha translationalinformaticsfornaturalproductsasantidepressantagents
AT shenli translationalinformaticsfornaturalproductsasantidepressantagents
AT shenbairong translationalinformaticsfornaturalproductsasantidepressantagents