Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes

BACKGROUND: Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TIL) yielded clinical benefit in patients with checkpoint blockade immunotherapy-refractory non-small cell lung cancer (NSCLC) prompting a renewed interest in TIL-ACT. This preclinical study explores the feasibility of produ...

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Detalles Bibliográficos
Autores principales: Shah, Parin, Forget, Marie-Andrée, Frank, Meredith L, Jiang, Peixin, Sakellariou-Thompson, Donastas, Federico, Lorenzo, Khairullah, Roohussaba, Neutzler, Chantal Alexia, Wistuba, Ignacio, Chow, Chi-Wan B, Long, Yan, Fujimoto, Junya, Lin, Shiaw-Yih, Maitra, Anirban, Negrao, Marcelo V, Mitchell, Kyle Gregory, Weissferdt, Annikka, Vaporciyan, Ara A, Cascone, Tina, Roth, Jack A, Zhang, Jianjun, Sepesi, Boris, Gibbons, Don L, Heymach, John V, Haymaker, Cara L, McGrail, Daniel J, Reuben, Alexandre, Bernatchez, Chantale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811607/
https://www.ncbi.nlm.nih.gov/pubmed/35110355
http://dx.doi.org/10.1136/jitc-2021-003082

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