Exploitation of the ribosomal protein L10 R98S mutation to enhance recombinant protein production in mammalian cells

Mammalian cells are commonly used to produce recombinant protein therapeutics, but suffer from a high cost per mg of protein produced. There is therefore great interest in improving protein yields to reduce production cost. We present an entirely novel approach to reach this goal through direct engi...

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Detalles Bibliográficos
Autores principales: Verbelen, Benno, Girardi, Tiziana, Sulima, Sergey O., Vereecke, Stijn, Verstraete, Paulien, Verbeeck, Jelle, Royaert, Jonathan, Cinque, Sonia, Montanaro, Lorenzo, Penzo, Marianna, Imbrechts, Maya, Geukens, Nick, Geuens, Thomas, Dierckx, Koen, Pepe, Daniele, Kampen, Kim, De Keersmaecker, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811726/
https://www.ncbi.nlm.nih.gov/pubmed/35140557
http://dx.doi.org/10.1002/elsc.202100124

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