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Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability

[Image: see text] In recent years, a variety of new antibody formats have been developed. One of these formats allows the binding of one type of antibody to two different epitopes. This can for example be achieved by introduction of the “knob-into-hole” format and a combined CrossMab approach. Due t...

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Detalles Bibliográficos
Autores principales:	Grunert, Ingrid, Heinrich, Katrin, Ernst, Juliane, Hingar, Michael, Briguet, Alexandre, Leiss, Michael, Wuhrer, Manfred, Reusch, Dietmar, Bulau, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811765/ https://www.ncbi.nlm.nih.gov/pubmed/35128275 http://dx.doi.org/10.1021/acsomega.1c06305

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