Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail

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The SARS-CoV-2 receptor-binding domain (RBD) E406W mutation abrogates neutralization mediated by the REGEN-CoV therapeutic monoclonal antibody (mAb) COVID-19 cocktail and the cilgavimab (AZD1061) mAb. Here, we show that this residue substitution remodels the ACE2-binding site allosterically, thereby...

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Detalles Bibliográficos
Autores principales: Addetia, Amin, Park, Young-Jun, Starr, Tyler, Greaney, Allison J., Sprouse, Kaitlin R, Bowen, John E., Tiles, Sasha W., Van Voorhis, Wesley C., Bloom, Jesse D., Corti, Davide, Walls, Alexandra C., Veesler, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811904/
https://www.ncbi.nlm.nih.gov/pubmed/35118471
http://dx.doi.org/10.1101/2022.01.21.477288

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