Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

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Immunization with SARS-CoV-2 spike elicits diverse antibodies, but can any of these neutralize broadly? Here, we report the isolation and characterization of antibody WS6, from a mouse immunized with mRNA encoding the SARS-CoV-2 spike. WS6 bound diverse beta-coronavirus spikes and neutralized SARS-C...

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Detalles Bibliográficos
Autores principales: Shi, Wei, Wang, Lingshu, Zhou, Tongqing, Sastry, Mallika, Yang, Eun Sung, Zhang, Yi, Chen, Man, Chen, Xuejun, Choe, Misook, Creanga, Adrian, Leung, Kwan, Olia, Adam S., Pegu, Amarendra, Rawi, Reda, Shen, Chen-Hsiang, Stancofski, Erik-Stephane D., Talana, Chloe Adrienna, Teng, I-Ting, Wang, Shuishu, Corbett, Kizzmekia S., Tsybovsky, Yaroslav, Mascola, John R., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811906/
https://www.ncbi.nlm.nih.gov/pubmed/35118472
http://dx.doi.org/10.1101/2022.01.25.477770
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