Proteomic Changes in the Monolayer and Spheroid Melanoma Cell Models of Acquired Resistance to BRAF and MEK1/2 Inhibitors

[Image: see text] Extracellular signal-regulated kinase-1/2 (ERK1/2) pathway inhibitors are important therapies for treating many cancers. However, acquired resistance to most protein kinase inhibitors limits their ability to provide durable responses. Approximately 50% of malignant melanomas contai...

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Autores principales: Martinez, Ramon, Huang, Weiliang, Buck, Heather, Rea, Samantha, Defnet, Amy E., Kane, Maureen A., Shapiro, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811929/
https://www.ncbi.nlm.nih.gov/pubmed/35128241
http://dx.doi.org/10.1021/acsomega.1c05361

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