Cargando…

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

BACKGROUND: One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide into amyloid plaques. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD and has been shown to influence the accumulation of Aβ in the br...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mahan, Thomas E., Wang, Chao, Bao, Xin, Choudhury, Ankit, Ulrich, Jason D., Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811969/ https://www.ncbi.nlm.nih.gov/pubmed/35109920 http://dx.doi.org/10.1186/s13024-022-00516-0

Ejemplares similares

ApoE facilitates the microglial response to amyloid plaque pathology
por: Ulrich, Jason D., et al.
Publicado: (2018)

ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype
por: Caesar, Ina, et al.
Publicado: (2023)

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
por: Kim, Jungsu, et al.
Publicado: (2012)

ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes
por: Keable, Abby, et al.
Publicado: (2020)

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
por: Huynh, Tien-Phat V., et al.
Publicado: (2019)

Astrocytic apoE4 and tau: Deadly combination for neurons
por: Chakrabarty, Paramita, et al.
Publicado: (2021)

Tryptase Promotes Atherosclerotic Plaque Haemorrhage in ApoE-/- Mice
por: Zhi, Xiuling, et al.
Publicado: (2013)

ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis
por: Staurenghi, Erica, et al.
Publicado: (2022)

ApoE and apoE receptors in brain lipid metabolism and AD
por: Bu, Guojun
Publicado: (2012)

Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors
por: Bu, Guojun, et al.
Publicado: (2013)

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice
por: Hu, Jin, et al.
Publicado: (2015)

Lipoprotein glomerulopathy induced by ApoE Kyoto mutation in ApoE-deficient mice
por: Wu, Hongyan, et al.
Publicado: (2021)

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy
por: Camacho, Jessica, et al.
Publicado: (2019)

Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE
por: Parhizkar, Samira, et al.
Publicado: (2019)

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
por: Qi, Guoyuan, et al.
Publicado: (2021)

Commentary: Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
por: Dzianok, Patrycja, et al.
Publicado: (2020)

Dystrophin deficiency reduces atherosclerotic plaque development in ApoE-null mice
por: Shami, Annelie, et al.
Publicado: (2015)

Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE(−/−) mice
por: Chen, Junwen, et al.
Publicado: (2014)

Annexin A5 reduces early plaque formation in ApoE -/- mice
por: Stöhr, Robert, et al.
Publicado: (2017)

Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE(−/−) Mice
por: Kim, Sungmin, et al.
Publicado: (2022)

SFRP4 Reduces Atherosclerosis Plaque Formation in ApoE Deficient Mice
por: Guan, Hua, et al.
Publicado: (2023)

Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice
por: Pankiewicz, Joanna E, et al.
Publicado: (2014)

ApoE polymorphisms in narcolepsy
por: Gencik, Martin, et al.
Publicado: (2001)

Potential role of ATM in hepatocyte endocytosis of ApoE-deficient, ApoB48-containing lipoprotein in ApoE-deficient mice
por: WU, JIANHUA, et al.
Publicado: (2014)

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype
por: Christensen, Ditte Z., et al.
Publicado: (2010)

Mercury Ion Binding to Apolipoprotein E Variants ApoE2, ApoE3, and ApoE4: Similar Binding Affinities but Different Structure Induction Effects
por: Berntsson, Elina, et al.
Publicado: (2022)

The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
por: Lau, Shun-Fat, et al.
Publicado: (2023)

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
por: Liraz, Ori, et al.
Publicado: (2013)

Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis
por: Mattsson, Niklas, et al.
Publicado: (2016)

Lack of ApoE inhibits ADan amyloidosis in a mouse model of familial Danish dementia
por: Fernandez, Anllely, et al.
Publicado: (2022)

Lipolysis-Stimulated Lipoprotein Receptor Acts as Sensor to Regulate ApoE Release in Astrocytes
por: Herzine, Ameziane, et al.
Publicado: (2022)

Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
por: Liu, Ya-Jing, et al.
Publicado: (2021)

MicroRNA-33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE(−/−) Mice
por: Horie, Takahiro, et al.
Publicado: (2012)

Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice
por: Grootaert, Mandy O. J., et al.
Publicado: (2016)

Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoE(-/-) mice
por: Li, Xin, et al.
Publicado: (2017)

ApoE4 upregulates the activity of mitochondria‐associated ER membranes
por: Tambini, Marc D, et al.
Publicado: (2015)

Neonatal Subcutaneous BCG Vaccination Decreases Atherosclerotic Plaque Number and Plaque Macrophage Content in ApoE(−/−) Mice
por: Bekkering, Siroon, et al.
Publicado: (2022)

CSF biomarkers for Alzheimer's pathology and the effect size of APOE ɛ4
por: Andreasson, U, et al.
Publicado: (2014)

Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology
por: Koren-Iton, Amit, et al.
Publicado: (2020)

Apolipoprotein E (ApoE) ε4 Genotype (ApoE rs429358—ApoE rs7412 Polymorphisms) Is Not Associated with Long COVID Symptoms in Previously Hospitalized COVID-19 Survivors
por: Fernández-de-las-Peñas, César, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hslnh2tgkipjp7k0dj4gp8bdqr