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Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

BACKGROUND: One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide into amyloid plaques. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD and has been shown to influence the accumulation of Aβ in the br...

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Detalles Bibliográficos
Autores principales:	Mahan, Thomas E., Wang, Chao, Bao, Xin, Choudhury, Ankit, Ulrich, Jason D., Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811969/ https://www.ncbi.nlm.nih.gov/pubmed/35109920 http://dx.doi.org/10.1186/s13024-022-00516-0

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