Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, the roles of ROS and exosomes in the process of M1 macrophage polarization are not known. Her...

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Autores principales: Liu, Chao, Hu, Fanqi, Jiao, Genlong, Guo, Yue, Zhou, Pan, Zhang, Yuning, Zhang, Zhen, Yi, Jing, You, Yonggang, Li, Zhizhong, Wang, Hua, Zhang, Xuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811988/
https://www.ncbi.nlm.nih.gov/pubmed/35109874
http://dx.doi.org/10.1186/s12951-022-01273-4
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author Liu, Chao
Hu, Fanqi
Jiao, Genlong
Guo, Yue
Zhou, Pan
Zhang, Yuning
Zhang, Zhen
Yi, Jing
You, Yonggang
Li, Zhizhong
Wang, Hua
Zhang, Xuesong
author_facet Liu, Chao
Hu, Fanqi
Jiao, Genlong
Guo, Yue
Zhou, Pan
Zhang, Yuning
Zhang, Zhen
Yi, Jing
You, Yonggang
Li, Zhizhong
Wang, Hua
Zhang, Xuesong
author_sort Liu, Chao
collection PubMed
description Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, the roles of ROS and exosomes in the process of M1 macrophage polarization are not known. Herein, we demonstrated that ROS can induce M1 macrophage polarization and have a concentration-dependent effect. ROS can induce M1 macrophage polarization through the MAPK-NFκB P65 signaling pathway. Dental pulp stem cell (DPSC)-derived exosomes can reduce macrophage M1 polarization through the ROS-MAPK-NFκB P65 signaling pathway in treating SCI. This study suggested that DPSC-derived exosomes might be a potential drug for treating SCI. Disruption of the cycle between ROS and M1 macrophage polarization might also be a potential effective treatment by reducing secondary damage. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01273-4.
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spelling pubmed-88119882022-02-03 Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury Liu, Chao Hu, Fanqi Jiao, Genlong Guo, Yue Zhou, Pan Zhang, Yuning Zhang, Zhen Yi, Jing You, Yonggang Li, Zhizhong Wang, Hua Zhang, Xuesong J Nanobiotechnology Research Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, the roles of ROS and exosomes in the process of M1 macrophage polarization are not known. Herein, we demonstrated that ROS can induce M1 macrophage polarization and have a concentration-dependent effect. ROS can induce M1 macrophage polarization through the MAPK-NFκB P65 signaling pathway. Dental pulp stem cell (DPSC)-derived exosomes can reduce macrophage M1 polarization through the ROS-MAPK-NFκB P65 signaling pathway in treating SCI. This study suggested that DPSC-derived exosomes might be a potential drug for treating SCI. Disruption of the cycle between ROS and M1 macrophage polarization might also be a potential effective treatment by reducing secondary damage. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01273-4. BioMed Central 2022-02-02 /pmc/articles/PMC8811988/ /pubmed/35109874 http://dx.doi.org/10.1186/s12951-022-01273-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liu, Chao
Hu, Fanqi
Jiao, Genlong
Guo, Yue
Zhou, Pan
Zhang, Yuning
Zhang, Zhen
Yi, Jing
You, Yonggang
Li, Zhizhong
Wang, Hua
Zhang, Xuesong
Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury
title Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury
title_full Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury
title_fullStr Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury
title_full_unstemmed Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury
title_short Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury
title_sort dental pulp stem cell-derived exosomes suppress m1 macrophage polarization through the ros-mapk-nfκb p65 signaling pathway after spinal cord injury
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811988/
https://www.ncbi.nlm.nih.gov/pubmed/35109874
http://dx.doi.org/10.1186/s12951-022-01273-4
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