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Changes in adipokine levels and metabolic profiles following bariatric surgery

BACKGROUND: Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients. Abdominal obesity is frequently accompanied by metabolic syndrome (MS). Adipokines are cell signaling proteins that have direct impact upon the metabolic homeostasis. The pur...

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Autores principales: Šebunova, Natalja, Štšepetova, Jelena, Kullisaar, Tiiu, Suija, Kadri, Rätsep, Anneli, Junkin, Igor, Soeorg, Hiie, Lember, Margus, Sillakivi, Toomas, Mändar, Reet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812034/
https://www.ncbi.nlm.nih.gov/pubmed/35114975
http://dx.doi.org/10.1186/s12902-022-00942-7
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author Šebunova, Natalja
Štšepetova, Jelena
Kullisaar, Tiiu
Suija, Kadri
Rätsep, Anneli
Junkin, Igor
Soeorg, Hiie
Lember, Margus
Sillakivi, Toomas
Mändar, Reet
author_facet Šebunova, Natalja
Štšepetova, Jelena
Kullisaar, Tiiu
Suija, Kadri
Rätsep, Anneli
Junkin, Igor
Soeorg, Hiie
Lember, Margus
Sillakivi, Toomas
Mändar, Reet
author_sort Šebunova, Natalja
collection PubMed
description BACKGROUND: Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients. Abdominal obesity is frequently accompanied by metabolic syndrome (MS). Adipokines are cell signaling proteins that have direct impact upon the metabolic homeostasis. The purpose of this analysis was to evaluate the effect of bariatric surgery, including laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric bypass (LRYGB) on the adipokine levels and metabolic profile as well as MS and status of type 2 diabetes (T2D). METHODS: We analyzed anthropometric parameters, blood levels of adipokines, vitamins, lipids and inflammatory markers in 30 bariatric surgery patients with obesity of class II or III 1 month before and 1 year after surgery as well as in 60 obese patients from general practice (GP) and 15 patients with normal body mass (control). RESULTS: The BMI was significantly higher among patients before surgery and GP patients in comparison to control and post-surgery patients. The levels of glucose, cholesterol and LDL-cholesterol, triglyceride and hs-CRP were the highest in patients before surgery but decreased significantly after surgery, while the level of HDL-cholesterol increased after surgery. The levels of adiponectin increased and that of leptin decreased after surgery. The significant difference in the concentration of resistin was revealed between LSG and LRYGB methods. The relationship between resistin and vitamin D was also found. The patients with MS and T2D displayed significantly greater reduction in lipid markers and adipokine levels than the rest of patients. CONCLUSION: Remarkable changes in levels of adipokines after bariatric surgery appear like increase in adiponectin and decrease in leptin levels. Significant improvement in anthropometric parameters, metabolic and inflammatory markers occurs, suggesting high potential for reduction of metabolic syndrome and risk for type 2 diabetes. We have shown for the first time ever that level of vitamin D may be involved in resistin regulation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-022-00942-7.
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spelling pubmed-88120342022-02-03 Changes in adipokine levels and metabolic profiles following bariatric surgery Šebunova, Natalja Štšepetova, Jelena Kullisaar, Tiiu Suija, Kadri Rätsep, Anneli Junkin, Igor Soeorg, Hiie Lember, Margus Sillakivi, Toomas Mändar, Reet BMC Endocr Disord Research BACKGROUND: Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients. Abdominal obesity is frequently accompanied by metabolic syndrome (MS). Adipokines are cell signaling proteins that have direct impact upon the metabolic homeostasis. The purpose of this analysis was to evaluate the effect of bariatric surgery, including laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric bypass (LRYGB) on the adipokine levels and metabolic profile as well as MS and status of type 2 diabetes (T2D). METHODS: We analyzed anthropometric parameters, blood levels of adipokines, vitamins, lipids and inflammatory markers in 30 bariatric surgery patients with obesity of class II or III 1 month before and 1 year after surgery as well as in 60 obese patients from general practice (GP) and 15 patients with normal body mass (control). RESULTS: The BMI was significantly higher among patients before surgery and GP patients in comparison to control and post-surgery patients. The levels of glucose, cholesterol and LDL-cholesterol, triglyceride and hs-CRP were the highest in patients before surgery but decreased significantly after surgery, while the level of HDL-cholesterol increased after surgery. The levels of adiponectin increased and that of leptin decreased after surgery. The significant difference in the concentration of resistin was revealed between LSG and LRYGB methods. The relationship between resistin and vitamin D was also found. The patients with MS and T2D displayed significantly greater reduction in lipid markers and adipokine levels than the rest of patients. CONCLUSION: Remarkable changes in levels of adipokines after bariatric surgery appear like increase in adiponectin and decrease in leptin levels. Significant improvement in anthropometric parameters, metabolic and inflammatory markers occurs, suggesting high potential for reduction of metabolic syndrome and risk for type 2 diabetes. We have shown for the first time ever that level of vitamin D may be involved in resistin regulation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-022-00942-7. BioMed Central 2022-02-03 /pmc/articles/PMC8812034/ /pubmed/35114975 http://dx.doi.org/10.1186/s12902-022-00942-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Šebunova, Natalja
Štšepetova, Jelena
Kullisaar, Tiiu
Suija, Kadri
Rätsep, Anneli
Junkin, Igor
Soeorg, Hiie
Lember, Margus
Sillakivi, Toomas
Mändar, Reet
Changes in adipokine levels and metabolic profiles following bariatric surgery
title Changes in adipokine levels and metabolic profiles following bariatric surgery
title_full Changes in adipokine levels and metabolic profiles following bariatric surgery
title_fullStr Changes in adipokine levels and metabolic profiles following bariatric surgery
title_full_unstemmed Changes in adipokine levels and metabolic profiles following bariatric surgery
title_short Changes in adipokine levels and metabolic profiles following bariatric surgery
title_sort changes in adipokine levels and metabolic profiles following bariatric surgery
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812034/
https://www.ncbi.nlm.nih.gov/pubmed/35114975
http://dx.doi.org/10.1186/s12902-022-00942-7
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