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Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey
BACKGROUND: The combination of antipsychotics is not well studied among non-psychotic major depressive disorder (MDD). This study aims to explore the antipsychotics use in this population and its associated factors. METHODS: This cross-sectional and multi-site study was conducted in 11 sites of Chin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812172/ https://www.ncbi.nlm.nih.gov/pubmed/35114977 http://dx.doi.org/10.1186/s12888-021-03411-y |
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author | Zhou, Jingjing Zhu, Tong Zhu, Xuequan Galling, Britta Xiao, Le |
author_facet | Zhou, Jingjing Zhu, Tong Zhu, Xuequan Galling, Britta Xiao, Le |
author_sort | Zhou, Jingjing |
collection | PubMed |
description | BACKGROUND: The combination of antipsychotics is not well studied among non-psychotic major depressive disorder (MDD). This study aims to explore the antipsychotics use in this population and its associated factors. METHODS: This cross-sectional and multi-site study was conducted in 11 sites of China. one Thousand five hundred three eligible MDD patients after 8–12 weeks of antidepressant treatment were included consecutively. A structured questionnaire was used to obtain socio-demographic data and medical histories. The Chinese version of the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR), the Patient Health Questionnaire-15 (PHQ-15) and the Sheehan Disability Scale (SDS) were used for patient self-rating. Logistic regression model was used to explore the associated factors that could potentially be influential for the use antipsychotic augmentation. RESULTS: Overall, quetiapine (43.4%) was the most commonly used as an adjunct to antidepressants, followed by olanzapine (38.8%). And antipsychotics were commonly combined with escitalopram (23.1%), venlafaxine (21.7%), sertraline (14.8%). The factors influencing the combination of antipsychotics in non-psychotic depressed patients included service setting (OR = 0.444; p < 0.001; 95%CI = 0.338–0.583), comorbidity of physical illness (OR = 1.704; p < 0.001; 95%CI = 1.274–2.278), PHQ level (OR = 0.680; p < 0.001; 95%CI = 0.548–0.844), SDS level (OR = 1.627; p < 0.001; 95%CI = 1.371–1.930) and antidepressants co-treatment (OR = 2.606; p < 0.001; 95%CI = 1.949–3.485). CONCLUSIONS: Antipsychotics use is common among non-psychotic MDD patient. Service setting, comorbidity of physical illness, somatic symptoms, social functioning and engagement, and antidepressants co-treatment could be the factors associated with the antipsychotics use in MDD patients. |
format | Online Article Text |
id | pubmed-8812172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-88121722022-02-03 Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey Zhou, Jingjing Zhu, Tong Zhu, Xuequan Galling, Britta Xiao, Le BMC Psychiatry Research BACKGROUND: The combination of antipsychotics is not well studied among non-psychotic major depressive disorder (MDD). This study aims to explore the antipsychotics use in this population and its associated factors. METHODS: This cross-sectional and multi-site study was conducted in 11 sites of China. one Thousand five hundred three eligible MDD patients after 8–12 weeks of antidepressant treatment were included consecutively. A structured questionnaire was used to obtain socio-demographic data and medical histories. The Chinese version of the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR), the Patient Health Questionnaire-15 (PHQ-15) and the Sheehan Disability Scale (SDS) were used for patient self-rating. Logistic regression model was used to explore the associated factors that could potentially be influential for the use antipsychotic augmentation. RESULTS: Overall, quetiapine (43.4%) was the most commonly used as an adjunct to antidepressants, followed by olanzapine (38.8%). And antipsychotics were commonly combined with escitalopram (23.1%), venlafaxine (21.7%), sertraline (14.8%). The factors influencing the combination of antipsychotics in non-psychotic depressed patients included service setting (OR = 0.444; p < 0.001; 95%CI = 0.338–0.583), comorbidity of physical illness (OR = 1.704; p < 0.001; 95%CI = 1.274–2.278), PHQ level (OR = 0.680; p < 0.001; 95%CI = 0.548–0.844), SDS level (OR = 1.627; p < 0.001; 95%CI = 1.371–1.930) and antidepressants co-treatment (OR = 2.606; p < 0.001; 95%CI = 1.949–3.485). CONCLUSIONS: Antipsychotics use is common among non-psychotic MDD patient. Service setting, comorbidity of physical illness, somatic symptoms, social functioning and engagement, and antidepressants co-treatment could be the factors associated with the antipsychotics use in MDD patients. BioMed Central 2022-02-03 /pmc/articles/PMC8812172/ /pubmed/35114977 http://dx.doi.org/10.1186/s12888-021-03411-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhou, Jingjing Zhu, Tong Zhu, Xuequan Galling, Britta Xiao, Le Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey |
title | Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey |
title_full | Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey |
title_fullStr | Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey |
title_full_unstemmed | Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey |
title_short | Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey |
title_sort | factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812172/ https://www.ncbi.nlm.nih.gov/pubmed/35114977 http://dx.doi.org/10.1186/s12888-021-03411-y |
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