Functions, mechanisms, and therapeutic implications of METTL14 in human cancer

RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, N(6)-methyladenine (m(6)A) is the most abundant RNA modification. Methyltransferase-like 14 (METTL14) is the central component of the m(6)A methyl...

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Autores principales: Guan, Qian, Lin, Huiran, Miao, Lei, Guo, Huiqin, Chen, Yongping, Zhuo, Zhenjian, He, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812173/
https://www.ncbi.nlm.nih.gov/pubmed/35115038
http://dx.doi.org/10.1186/s13045-022-01231-5
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author Guan, Qian
Lin, Huiran
Miao, Lei
Guo, Huiqin
Chen, Yongping
Zhuo, Zhenjian
He, Jing
author_facet Guan, Qian
Lin, Huiran
Miao, Lei
Guo, Huiqin
Chen, Yongping
Zhuo, Zhenjian
He, Jing
author_sort Guan, Qian
collection PubMed
description RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, N(6)-methyladenine (m(6)A) is the most abundant RNA modification. Methyltransferase-like 14 (METTL14) is the central component of the m(6)A methylated transferase complex, which is involved in the dynamic reversible process of m(6)A modification. METTL14 acts as both an oncogene and tumor suppressor gene to regulate the occurrence and development of various cancers. The abnormal m(6)A level induced by METTL14 is related to tumorigenesis, proliferation, metastasis, and invasion. To date, the molecular mechanism of METTL14 in various malignant tumors has not been fully studied. In this paper, we systematically summarize the latest research progress on METTL14 as a new biomarker for cancer diagnosis and its biological function in human tumors and discuss its potential clinical application. This study aims to provide new ideas for targeted therapy and improved prognoses in cancer.
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spelling pubmed-88121732022-02-03 Functions, mechanisms, and therapeutic implications of METTL14 in human cancer Guan, Qian Lin, Huiran Miao, Lei Guo, Huiqin Chen, Yongping Zhuo, Zhenjian He, Jing J Hematol Oncol Review RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, N(6)-methyladenine (m(6)A) is the most abundant RNA modification. Methyltransferase-like 14 (METTL14) is the central component of the m(6)A methylated transferase complex, which is involved in the dynamic reversible process of m(6)A modification. METTL14 acts as both an oncogene and tumor suppressor gene to regulate the occurrence and development of various cancers. The abnormal m(6)A level induced by METTL14 is related to tumorigenesis, proliferation, metastasis, and invasion. To date, the molecular mechanism of METTL14 in various malignant tumors has not been fully studied. In this paper, we systematically summarize the latest research progress on METTL14 as a new biomarker for cancer diagnosis and its biological function in human tumors and discuss its potential clinical application. This study aims to provide new ideas for targeted therapy and improved prognoses in cancer. BioMed Central 2022-02-03 /pmc/articles/PMC8812173/ /pubmed/35115038 http://dx.doi.org/10.1186/s13045-022-01231-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Guan, Qian
Lin, Huiran
Miao, Lei
Guo, Huiqin
Chen, Yongping
Zhuo, Zhenjian
He, Jing
Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
title Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
title_full Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
title_fullStr Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
title_full_unstemmed Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
title_short Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
title_sort functions, mechanisms, and therapeutic implications of mettl14 in human cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812173/
https://www.ncbi.nlm.nih.gov/pubmed/35115038
http://dx.doi.org/10.1186/s13045-022-01231-5
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