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Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings
OBJECTIVES: To review retrospectively atypical bone findings from computed tomographic (CT) imaging in patients with Erdheim–Chester disease. METHODS: All 28 patients with Erdheim–Chester disease (13 men and 15 women; mean age, 45 years; range, 7–63 years) underwent chest-abdomen-pelvis CT. CT image...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812243/ https://www.ncbi.nlm.nih.gov/pubmed/35115034 http://dx.doi.org/10.1186/s13023-022-02185-0 |
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author | Zhang, Zaizhu Yu, Wei Guan, Wenmin Lin, Qiang Guermazi, Ali |
author_facet | Zhang, Zaizhu Yu, Wei Guan, Wenmin Lin, Qiang Guermazi, Ali |
author_sort | Zhang, Zaizhu |
collection | PubMed |
description | OBJECTIVES: To review retrospectively atypical bone findings from computed tomographic (CT) imaging in patients with Erdheim–Chester disease. METHODS: All 28 patients with Erdheim–Chester disease (13 men and 15 women; mean age, 45 years; range, 7–63 years) underwent chest-abdomen-pelvis CT. CT images were reviewed and analyzed for the various features of atypical bone lesions by two radiologists in consensus. RESULTS: Twenty-one patients had atypical bone involvement. Radiologically, these atypical osseous lesions were categorized into three types: diffuse, nodular and patchy. Eleven (52%) of the 21 patients had spinal lesions, of which four (36%) had the diffuse type, eight (73%) had the nodular pattern, and six (55%) had the patchy pattern. Sixteen (76%) of the 21 patients had pelvic involvement, of which two (13%) were diffuse, nine (56%) were nodular and 11 were (69%) patchy. Ribs were involved in seven (33%) of the 21 patients, with the nodular pattern in one (14%) patient and the patchy type in six (86%) patients. Clavicle involvement was seen in nine (43%) of the 21 patients, of which the diffuse type was found in only one (11%) patient, the nodular type in six (67%) patients, the solitary patchy type in four (44%) patients. Sternum involvement was seen in 10 (48%) of the 21 patients and all were nodular. CONCLUSIONS: This series provides a detailed description of atypical bone involvement in Erdheim–Chester disease which on CT displays three major patterns. Understanding these patterns may help increase the accuracy of diagnosis of this disease. |
format | Online Article Text |
id | pubmed-8812243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-88122432022-02-07 Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings Zhang, Zaizhu Yu, Wei Guan, Wenmin Lin, Qiang Guermazi, Ali Orphanet J Rare Dis Research OBJECTIVES: To review retrospectively atypical bone findings from computed tomographic (CT) imaging in patients with Erdheim–Chester disease. METHODS: All 28 patients with Erdheim–Chester disease (13 men and 15 women; mean age, 45 years; range, 7–63 years) underwent chest-abdomen-pelvis CT. CT images were reviewed and analyzed for the various features of atypical bone lesions by two radiologists in consensus. RESULTS: Twenty-one patients had atypical bone involvement. Radiologically, these atypical osseous lesions were categorized into three types: diffuse, nodular and patchy. Eleven (52%) of the 21 patients had spinal lesions, of which four (36%) had the diffuse type, eight (73%) had the nodular pattern, and six (55%) had the patchy pattern. Sixteen (76%) of the 21 patients had pelvic involvement, of which two (13%) were diffuse, nine (56%) were nodular and 11 were (69%) patchy. Ribs were involved in seven (33%) of the 21 patients, with the nodular pattern in one (14%) patient and the patchy type in six (86%) patients. Clavicle involvement was seen in nine (43%) of the 21 patients, of which the diffuse type was found in only one (11%) patient, the nodular type in six (67%) patients, the solitary patchy type in four (44%) patients. Sternum involvement was seen in 10 (48%) of the 21 patients and all were nodular. CONCLUSIONS: This series provides a detailed description of atypical bone involvement in Erdheim–Chester disease which on CT displays three major patterns. Understanding these patterns may help increase the accuracy of diagnosis of this disease. BioMed Central 2022-02-03 /pmc/articles/PMC8812243/ /pubmed/35115034 http://dx.doi.org/10.1186/s13023-022-02185-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhang, Zaizhu Yu, Wei Guan, Wenmin Lin, Qiang Guermazi, Ali Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings |
title | Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings |
title_full | Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings |
title_fullStr | Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings |
title_full_unstemmed | Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings |
title_short | Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings |
title_sort | atypical skeletal involvement in patients with erdheim–chester disease: ct imaging findings |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812243/ https://www.ncbi.nlm.nih.gov/pubmed/35115034 http://dx.doi.org/10.1186/s13023-022-02185-0 |
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