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Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women

BACKGROUND: Ovarian reserve declines with age. However, there are considerable ethnic differences in the decline of ovarian reserve between individuals. AIM: This study aimed to make age-specific percentile charts of anti-Mullerian hormone (AMH) and antral follicle count (AFC) in Indian infertile wo...

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Autores principales: Gunasheela, Devika, Murali, Rajaam, Appaneravanda, Lohith Chengappa, Gerstl, Brigitte, Kumar, Arun, Sengeetha, Nishanthini, Nayak, Hita, Chandrikadevi, P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812401/
https://www.ncbi.nlm.nih.gov/pubmed/35197682
http://dx.doi.org/10.4103/jhrs.jhrs_65_21
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author Gunasheela, Devika
Murali, Rajaam
Appaneravanda, Lohith Chengappa
Gerstl, Brigitte
Kumar, Arun
Sengeetha, Nishanthini
Nayak, Hita
Chandrikadevi, P. M.
author_facet Gunasheela, Devika
Murali, Rajaam
Appaneravanda, Lohith Chengappa
Gerstl, Brigitte
Kumar, Arun
Sengeetha, Nishanthini
Nayak, Hita
Chandrikadevi, P. M.
author_sort Gunasheela, Devika
collection PubMed
description BACKGROUND: Ovarian reserve declines with age. However, there are considerable ethnic differences in the decline of ovarian reserve between individuals. AIM: This study aimed to make age-specific percentile charts of anti-Mullerian hormone (AMH) and antral follicle count (AFC) in Indian infertile women and to find the proportion of young women with low ovarian reserve. SETTING AND DESIGN: This was a retrospective data analysis of AMH and AFC of 5525 infertile women from August 2015 to December 2018. MATERIALS AND METHODS: Infertile women aged 20– 44 years, with body mass index 18–32 kg/m(2) and having both ovaries were included in the study. Women with pituitary/adrenal disorders, malignancy, total AFC >40, tuberculosis, endometriosis, autoimmune disorders, smoking, chemotherapy, radiotherapy and recent ovarian surgery were excluded from the study. STATISTICAL ANALYSIS: Comparison between groups was done by Chi-square test. RESULTS: About 14.5% of women <35 years and 50.5% of women >35 years had low AMH values (<1.1 ng/ml). In addition, 5.6% of women <35 years and 23.6% of women >35 years had a low AFC of ≤5. In this study, 55.7% of women who had low AMH and 50.7% who had low AFC were <35 years of age. The median AMH values were 4.23 ng/mL in 20–25 years’ age group, 3.48 ng/mL in women aged 26–30 years, 2.43 ng/mL in women aged 31–35 years, 1.28 ng/mL in women aged 36–40 years and0.52 ng/mL in 40–44 years’ age group. The median AFCs were 20, 18, 14, 10 and 6 for each of the age groups, respectively. CONCLUSION: This study suggests that approximately more than half of the infertile women who were tested to have low ovarian reserve were <35 years of age.
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spelling pubmed-88124012022-02-22 Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women Gunasheela, Devika Murali, Rajaam Appaneravanda, Lohith Chengappa Gerstl, Brigitte Kumar, Arun Sengeetha, Nishanthini Nayak, Hita Chandrikadevi, P. M. J Hum Reprod Sci Original Article BACKGROUND: Ovarian reserve declines with age. However, there are considerable ethnic differences in the decline of ovarian reserve between individuals. AIM: This study aimed to make age-specific percentile charts of anti-Mullerian hormone (AMH) and antral follicle count (AFC) in Indian infertile women and to find the proportion of young women with low ovarian reserve. SETTING AND DESIGN: This was a retrospective data analysis of AMH and AFC of 5525 infertile women from August 2015 to December 2018. MATERIALS AND METHODS: Infertile women aged 20– 44 years, with body mass index 18–32 kg/m(2) and having both ovaries were included in the study. Women with pituitary/adrenal disorders, malignancy, total AFC >40, tuberculosis, endometriosis, autoimmune disorders, smoking, chemotherapy, radiotherapy and recent ovarian surgery were excluded from the study. STATISTICAL ANALYSIS: Comparison between groups was done by Chi-square test. RESULTS: About 14.5% of women <35 years and 50.5% of women >35 years had low AMH values (<1.1 ng/ml). In addition, 5.6% of women <35 years and 23.6% of women >35 years had a low AFC of ≤5. In this study, 55.7% of women who had low AMH and 50.7% who had low AFC were <35 years of age. The median AMH values were 4.23 ng/mL in 20–25 years’ age group, 3.48 ng/mL in women aged 26–30 years, 2.43 ng/mL in women aged 31–35 years, 1.28 ng/mL in women aged 36–40 years and0.52 ng/mL in 40–44 years’ age group. The median AFCs were 20, 18, 14, 10 and 6 for each of the age groups, respectively. CONCLUSION: This study suggests that approximately more than half of the infertile women who were tested to have low ovarian reserve were <35 years of age. Wolters Kluwer - Medknow 2021 2021-12-31 /pmc/articles/PMC8812401/ /pubmed/35197682 http://dx.doi.org/10.4103/jhrs.jhrs_65_21 Text en Copyright: © 2021 Journal of Human Reproductive Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Gunasheela, Devika
Murali, Rajaam
Appaneravanda, Lohith Chengappa
Gerstl, Brigitte
Kumar, Arun
Sengeetha, Nishanthini
Nayak, Hita
Chandrikadevi, P. M.
Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women
title Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women
title_full Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women
title_fullStr Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women
title_full_unstemmed Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women
title_short Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women
title_sort age-specific distribution of serum anti-mullerian hormone and antral follicle count in indian infertile women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812401/
https://www.ncbi.nlm.nih.gov/pubmed/35197682
http://dx.doi.org/10.4103/jhrs.jhrs_65_21
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