Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug

We report two structures of the human voltage-gated potassium channel (Kv) Kv1.3 in immune cells alone (apo-Kv1.3) and bound to an immunomodulatory drug called dalazatide (dalazatide–Kv1.3). Both the apo-Kv1.3 and dalazatide–Kv1.3 structures are in an activated state based on their depolarized volta...

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Detalles Bibliográficos
Autores principales: Tyagi, Anu, Ahmed, Tofayel, Jian, Shi, Bajaj, Saumya, Ong, Seow Theng, Goay, Stephanie Shee Min, Zhao, Yue, Vorobyov, Igor, Tian, Changlin, Chandy, K. George, Bhushan, Shashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812516/
https://www.ncbi.nlm.nih.gov/pubmed/35091471
http://dx.doi.org/10.1073/pnas.2113536119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812516/
https://www.ncbi.nlm.nih.gov/pubmed/35091471
http://dx.doi.org/10.1073/pnas.2113536119

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