Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors

RAF inhibitors unexpectedly induce ERK signaling in normal and tumor cells with elevated RAS activity. Paradoxical activation is believed to be RAS dependent. In this study, we showed that LY3009120, a pan-RAF inhibitor, can unexpectedly cause paradoxical ERK activation in KRAS(G12C)-dependent lung...

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Detalles Bibliográficos
Autores principales: Lai, Lick Pui, Fer, Nicole, Burgan, William, Wall, Vanessa E., Xu, Bingfang, Soppet, Daniel, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812530/
https://www.ncbi.nlm.nih.gov/pubmed/35091470
http://dx.doi.org/10.1073/pnas.2113491119

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