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Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery
To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812578/ https://www.ncbi.nlm.nih.gov/pubmed/29069920 http://dx.doi.org/10.1080/10717544.2017.1388451 |
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author | Fang, Yan Xue, Jianxiu Gao, Shan Lu, Anqi Yang, Dongjuan Jiang, Hong He, Yang Shi, Kai |
author_facet | Fang, Yan Xue, Jianxiu Gao, Shan Lu, Anqi Yang, Dongjuan Jiang, Hong He, Yang Shi, Kai |
author_sort | Fang, Yan |
collection | PubMed |
description | To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape. As a result, the activity of drugs is inevitably lost after PEG modification. To achieve successful drug delivery for effective treatment, the crucial issue associated with the use of PEG-lipids, that is, “PEG dilemma” must be addressed. In this paper, we introduced the development and application of nanocarriers with cleavable PEGylation, and discussed various strategies for overcoming the PEG dilemma. Compared to the traditional ones, the vehicle systems with different environmental-sensitive PEG-lipids were discussed, which cleavage can be achieved in response to the intracellular as well as the tumor microenvironment. This smart cleavable PEGylation provides us an efficient strategy to overcome “PEG dilemma”, thereby may be a good candidate for the cancer treatment in future. |
format | Online Article Text |
id | pubmed-8812578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88125782022-02-04 Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery Fang, Yan Xue, Jianxiu Gao, Shan Lu, Anqi Yang, Dongjuan Jiang, Hong He, Yang Shi, Kai Drug Deliv Review To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape. As a result, the activity of drugs is inevitably lost after PEG modification. To achieve successful drug delivery for effective treatment, the crucial issue associated with the use of PEG-lipids, that is, “PEG dilemma” must be addressed. In this paper, we introduced the development and application of nanocarriers with cleavable PEGylation, and discussed various strategies for overcoming the PEG dilemma. Compared to the traditional ones, the vehicle systems with different environmental-sensitive PEG-lipids were discussed, which cleavage can be achieved in response to the intracellular as well as the tumor microenvironment. This smart cleavable PEGylation provides us an efficient strategy to overcome “PEG dilemma”, thereby may be a good candidate for the cancer treatment in future. Taylor & Francis 2017-10-25 /pmc/articles/PMC8812578/ /pubmed/29069920 http://dx.doi.org/10.1080/10717544.2017.1388451 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Fang, Yan Xue, Jianxiu Gao, Shan Lu, Anqi Yang, Dongjuan Jiang, Hong He, Yang Shi, Kai Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery |
title | Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery |
title_full | Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery |
title_fullStr | Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery |
title_full_unstemmed | Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery |
title_short | Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery |
title_sort | cleavable pegylation: a strategy for overcoming the “peg dilemma” in efficient drug delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812578/ https://www.ncbi.nlm.nih.gov/pubmed/29069920 http://dx.doi.org/10.1080/10717544.2017.1388451 |
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