Dendrimer-based contrast agents for PET imaging

Positron emission tomography (PET) imaging offers physiological and biological information through the in vivo distribution of PET agents for disease diagnosis, therapy monitoring and prognosis evaluation. Due to the unique structural characteristics allowing for facile modification of targeting lig...

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Detalles Bibliográficos
Autores principales: Zhao, Lingzhou, Shi, Xiangyang, Zhao, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812586/
https://www.ncbi.nlm.nih.gov/pubmed/29124984
http://dx.doi.org/10.1080/10717544.2017.1399299
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author Zhao, Lingzhou
Shi, Xiangyang
Zhao, Jinhua
author_facet Zhao, Lingzhou
Shi, Xiangyang
Zhao, Jinhua
author_sort Zhao, Lingzhou
collection PubMed
description Positron emission tomography (PET) imaging offers physiological and biological information through the in vivo distribution of PET agents for disease diagnosis, therapy monitoring and prognosis evaluation. Due to the unique structural characteristics allowing for facile modification of targeting ligands and radionuclides, dendrimers can be served as a versatile scaffold to build up various PET imaging agents, and significant breakthroughs have been made in this field over the past decades. This review focuses on the recent advances in dendrimer-based contrast agents for PET imaging of cancer, cardiovascular and other diseases. In particular, radiolabeling strategies for different PET isotopes are described in detail. Several challenges involved in clinical translation of radiolabeled dendrimers are also discussed.
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spelling pubmed-88125862022-02-04 Dendrimer-based contrast agents for PET imaging Zhao, Lingzhou Shi, Xiangyang Zhao, Jinhua Drug Deliv Review Positron emission tomography (PET) imaging offers physiological and biological information through the in vivo distribution of PET agents for disease diagnosis, therapy monitoring and prognosis evaluation. Due to the unique structural characteristics allowing for facile modification of targeting ligands and radionuclides, dendrimers can be served as a versatile scaffold to build up various PET imaging agents, and significant breakthroughs have been made in this field over the past decades. This review focuses on the recent advances in dendrimer-based contrast agents for PET imaging of cancer, cardiovascular and other diseases. In particular, radiolabeling strategies for different PET isotopes are described in detail. Several challenges involved in clinical translation of radiolabeled dendrimers are also discussed. Taylor & Francis 2017-11-10 /pmc/articles/PMC8812586/ /pubmed/29124984 http://dx.doi.org/10.1080/10717544.2017.1399299 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Zhao, Lingzhou
Shi, Xiangyang
Zhao, Jinhua
Dendrimer-based contrast agents for PET imaging
title Dendrimer-based contrast agents for PET imaging
title_full Dendrimer-based contrast agents for PET imaging
title_fullStr Dendrimer-based contrast agents for PET imaging
title_full_unstemmed Dendrimer-based contrast agents for PET imaging
title_short Dendrimer-based contrast agents for PET imaging
title_sort dendrimer-based contrast agents for pet imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812586/
https://www.ncbi.nlm.nih.gov/pubmed/29124984
http://dx.doi.org/10.1080/10717544.2017.1399299
work_keys_str_mv AT zhaolingzhou dendrimerbasedcontrastagentsforpetimaging
AT shixiangyang dendrimerbasedcontrastagentsforpetimaging
AT zhaojinhua dendrimerbasedcontrastagentsforpetimaging

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