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Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: A multi-institutional analysis using a clinical data warehouse

The study aims to evaluate the characteristics, treatments, and incidence rates of carpal tunnel syndrome (CTS) and tenosynovitis in women with breast cancer, according to the hormone therapy used. We retrospectively reviewed women with breast cancer identified from the clinical data warehouse of th...

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Autores principales: Shin, Dong Jae, Nam, Kyung Eun, Song, Dae Heon, Im, Sun, Won, Sun Jae, Kim, Yeo Hyung, Lim, Seong Hoon, Lee, Jong In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812623/
https://www.ncbi.nlm.nih.gov/pubmed/35119045
http://dx.doi.org/10.1097/MD.0000000000028786
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author Shin, Dong Jae
Nam, Kyung Eun
Song, Dae Heon
Im, Sun
Won, Sun Jae
Kim, Yeo Hyung
Lim, Seong Hoon
Lee, Jong In
author_facet Shin, Dong Jae
Nam, Kyung Eun
Song, Dae Heon
Im, Sun
Won, Sun Jae
Kim, Yeo Hyung
Lim, Seong Hoon
Lee, Jong In
author_sort Shin, Dong Jae
collection PubMed
description The study aims to evaluate the characteristics, treatments, and incidence rates of carpal tunnel syndrome (CTS) and tenosynovitis in women with breast cancer, according to the hormone therapy used. We retrospectively reviewed women with breast cancer identified from the clinical data warehouse of the six hospitals in Korea, from January 2015 to August 2020. Among them, patients with CTS or tenosynovitis were reviewed in terms of disease status and treatments. A total of 101 patients among a population of 15,504 met the study inclusion criteria, so their clinical data were analyzed. Aromatase inhibitor (AI) users frequently needed oral medication for CTS, and developed severe CTS which frequently required surgery. AI users presented with a higher incidence of CTS (1.3%) than patients without hormone therapy (0.4%), and tenosynovitis occurred at a higher rate in AI users (2.3%) compared to the tamoxifen (1.1%) and no hormone groups (0.5%). More than half of the CTS and tenosynovitis occurred within 12 months after hormone commencement. The incidence and disease characteristics of CTS and tenosynovitis differed among the groups depending on the type of hormone therapy received. Our findings will help clinicians understand clinical courses and treatments for CTS and tenosynovitis in breast cancer patients.
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spelling pubmed-88126232022-02-18 Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: A multi-institutional analysis using a clinical data warehouse Shin, Dong Jae Nam, Kyung Eun Song, Dae Heon Im, Sun Won, Sun Jae Kim, Yeo Hyung Lim, Seong Hoon Lee, Jong In Medicine (Baltimore) 6300 The study aims to evaluate the characteristics, treatments, and incidence rates of carpal tunnel syndrome (CTS) and tenosynovitis in women with breast cancer, according to the hormone therapy used. We retrospectively reviewed women with breast cancer identified from the clinical data warehouse of the six hospitals in Korea, from January 2015 to August 2020. Among them, patients with CTS or tenosynovitis were reviewed in terms of disease status and treatments. A total of 101 patients among a population of 15,504 met the study inclusion criteria, so their clinical data were analyzed. Aromatase inhibitor (AI) users frequently needed oral medication for CTS, and developed severe CTS which frequently required surgery. AI users presented with a higher incidence of CTS (1.3%) than patients without hormone therapy (0.4%), and tenosynovitis occurred at a higher rate in AI users (2.3%) compared to the tamoxifen (1.1%) and no hormone groups (0.5%). More than half of the CTS and tenosynovitis occurred within 12 months after hormone commencement. The incidence and disease characteristics of CTS and tenosynovitis differed among the groups depending on the type of hormone therapy received. Our findings will help clinicians understand clinical courses and treatments for CTS and tenosynovitis in breast cancer patients. Lippincott Williams & Wilkins 2022-02-04 /pmc/articles/PMC8812623/ /pubmed/35119045 http://dx.doi.org/10.1097/MD.0000000000028786 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 6300
Shin, Dong Jae
Nam, Kyung Eun
Song, Dae Heon
Im, Sun
Won, Sun Jae
Kim, Yeo Hyung
Lim, Seong Hoon
Lee, Jong In
Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: A multi-institutional analysis using a clinical data warehouse
title Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: A multi-institutional analysis using a clinical data warehouse
title_full Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: A multi-institutional analysis using a clinical data warehouse
title_fullStr Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: A multi-institutional analysis using a clinical data warehouse
title_full_unstemmed Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: A multi-institutional analysis using a clinical data warehouse
title_short Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: A multi-institutional analysis using a clinical data warehouse
title_sort carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy: a multi-institutional analysis using a clinical data warehouse
topic 6300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812623/
https://www.ncbi.nlm.nih.gov/pubmed/35119045
http://dx.doi.org/10.1097/MD.0000000000028786
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