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Mutant libraries reveal negative design shielding proteins from supramolecular self-assembly and relocalization in cells
Understanding the molecular consequences of mutations in proteins is essential to map genotypes to phenotypes and interpret the increasing wealth of genomic data. While mutations are known to disrupt protein structure and function, their potential to create new structures and localization phenotypes...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812688/ https://www.ncbi.nlm.nih.gov/pubmed/35078932 http://dx.doi.org/10.1073/pnas.2101117119 |