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Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation

Epithelial ovarian cancer (EOC) is the leading cause of deaths due to cancer in women. Adipocytes have been suggested to play a key role in the stimulation of EOC growth. However, the mechanisms underlying the adipocyte-induced EOC proliferation remain undefined. Here, we provide the first evidence...

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Autores principales: Dai, Lan, Wang, Chen, Wang, Wenjing, Song, Keqi, Ye, Taiyang, Zhu, Jie, Di, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812714/
https://www.ncbi.nlm.nih.gov/pubmed/35178477
http://dx.doi.org/10.1515/med-2022-0422
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author Dai, Lan
Wang, Chen
Wang, Wenjing
Song, Keqi
Ye, Taiyang
Zhu, Jie
Di, Wen
author_facet Dai, Lan
Wang, Chen
Wang, Wenjing
Song, Keqi
Ye, Taiyang
Zhu, Jie
Di, Wen
author_sort Dai, Lan
collection PubMed
description Epithelial ovarian cancer (EOC) is the leading cause of deaths due to cancer in women. Adipocytes have been suggested to play a key role in the stimulation of EOC growth. However, the mechanisms underlying the adipocyte-induced EOC proliferation remain undefined. Here, we provide the first evidence that adipocytes induce the activation of sphingosine kinase (SphK) 2 in EOC, which represents a novel pathway that mediates the adipocyte-induced EOC growth. SphK2 inhibition in EOC cells led to a remarkable inhibition of the adipocyte-induced cell proliferation. Moreover, the adipocyte-induced SphK2 activation in EOC cells was extracellular signal-regulated protein kinases (ERK) dependent. Furthermore, silencing SphK2 in EOC significantly inhibited the adipocyte-induced expression of phospho-ERK and c-Myc, two crucial players in EOC growth. Collectively, the current study unraveled a previously unrecognized role of SphK2 in the adipocyte-induced growth-promoting action in EOC, suggesting a novel target for EOC treatment.
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spelling pubmed-88127142022-02-16 Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation Dai, Lan Wang, Chen Wang, Wenjing Song, Keqi Ye, Taiyang Zhu, Jie Di, Wen Open Med (Wars) Research Article Epithelial ovarian cancer (EOC) is the leading cause of deaths due to cancer in women. Adipocytes have been suggested to play a key role in the stimulation of EOC growth. However, the mechanisms underlying the adipocyte-induced EOC proliferation remain undefined. Here, we provide the first evidence that adipocytes induce the activation of sphingosine kinase (SphK) 2 in EOC, which represents a novel pathway that mediates the adipocyte-induced EOC growth. SphK2 inhibition in EOC cells led to a remarkable inhibition of the adipocyte-induced cell proliferation. Moreover, the adipocyte-induced SphK2 activation in EOC cells was extracellular signal-regulated protein kinases (ERK) dependent. Furthermore, silencing SphK2 in EOC significantly inhibited the adipocyte-induced expression of phospho-ERK and c-Myc, two crucial players in EOC growth. Collectively, the current study unraveled a previously unrecognized role of SphK2 in the adipocyte-induced growth-promoting action in EOC, suggesting a novel target for EOC treatment. De Gruyter 2022-01-31 /pmc/articles/PMC8812714/ /pubmed/35178477 http://dx.doi.org/10.1515/med-2022-0422 Text en © 2022 Lan Dai et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Dai, Lan
Wang, Chen
Wang, Wenjing
Song, Keqi
Ye, Taiyang
Zhu, Jie
Di, Wen
Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
title Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
title_full Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
title_fullStr Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
title_full_unstemmed Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
title_short Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
title_sort activation of sphk2 contributes to adipocyte-induced eoc cell proliferation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812714/
https://www.ncbi.nlm.nih.gov/pubmed/35178477
http://dx.doi.org/10.1515/med-2022-0422
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