MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer

The oncogenic MUC1-C protein drives dedifferentiation of castrate resistant prostate cancer (CRPC) cells in association with chromatin remodeling. The present work demonstrates that MUC1-C is necessary for expression of IFNGR1 and activation of the type II interferon-gamma (IFN-γ) pathway. We show t...

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Detalles Bibliográficos
Autores principales: Hagiwara, Masayuki, Fushimi, Atsushi, Bhattacharya, Atrayee, Yamashita, Nami, Morimoto, Yoshihiro, Oya, Mototsugu, Withers, Henry G., Hu, Qiang, Liu, Tao, Liu, Song, Wong, Kwok K., Long, Mark D., Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812775/
https://www.ncbi.nlm.nih.gov/pubmed/35127252
http://dx.doi.org/10.1080/2162402X.2022.2029298

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