Pathogenicity and virulence of Hepatitis B virus

Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are an estimated 296 million people in the world that are chronically infected by this virus, and many of them will develop severe liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC)....

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Detalles Bibliográficos
Autores principales: Chuang, Yu-Chen, Tsai, Kuen-Nan, Ou, Jing-Hsiung James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Signature Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812780/
https://www.ncbi.nlm.nih.gov/pubmed/35100095
http://dx.doi.org/10.1080/21505594.2022.2028483
Descripción
Sumario:Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are an estimated 296 million people in the world that are chronically infected by this virus, and many of them will develop severe liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC). HBV is a small DNA virus that replicates via the reverse transcription pathway. In this review, we summarize the molecular pathways that govern the replication of HBV and its interactions with host cells. We also discuss viral and non-viral factors that are associated with HBV-induced carcinogenesis and pathogenesis, as well as the role of host immune responses in HBV persistence and liver pathogenesis.

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