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Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV
BACKGROUND: The dynamic of HIV-viral load (VL) remains poorly investigated in HIV/HCV patients under direct acting antivirals (DAAs). METHODS: We retrospectively evaluated HIV-VL at baseline (BL) during and up to 24 weeks post-DAAs in a cohort of 305 HIV-1/HCV patients, on ART and with no HIV virolo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812874/ https://www.ncbi.nlm.nih.gov/pubmed/35113890 http://dx.doi.org/10.1371/journal.pone.0262917 |
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author | Morsica, Giulia Galli, Laura Messina, Emanuela Castagna, Antonella Bagaglio, Sabrina Salpietro, Stefania Liviana, Della Torre Uberti-Foppa, Caterina Hasson, Hamid |
author_facet | Morsica, Giulia Galli, Laura Messina, Emanuela Castagna, Antonella Bagaglio, Sabrina Salpietro, Stefania Liviana, Della Torre Uberti-Foppa, Caterina Hasson, Hamid |
author_sort | Morsica, Giulia |
collection | PubMed |
description | BACKGROUND: The dynamic of HIV-viral load (VL) remains poorly investigated in HIV/HCV patients under direct acting antivirals (DAAs). METHODS: We retrospectively evaluated HIV-VL at baseline (BL) during and up to 24 weeks post-DAAs in a cohort of 305 HIV-1/HCV patients, on ART and with no HIV virological failure (VF) in the 6 months before treatment with DAAs; during the period of observation VF was defined as confirmed VL≥50 copies/mL; virological blips (VB, transient, not confirmed, VL ≥50 copies/mL). Stepwise Cox regression models were fitted to estimate adjusted hazard ratios (aHR) of VF. RESULTS: Fifteen VF occurred in 13 patients over 187 person-years of follow-up (PYFU): incidence rate (IR) of 8.0 per 100-PYFU (95% CI = 4.0–12.1); 29 VBs were detected in 26 patients over 184 PYFU: IR = 15.8 per 100-PYFU (95% CI = 10.0–21.5). The most prominent factor associated with VF was the presence of BL HIV residual viremia (RV = HIV-RNA detectable but not precisely quantifiable) [aHR = 12.26 (95% CI = 3.74–40.17), P<0.0001]. Other factors were ≥1 VBs in the 6 months before DAAs [aHR = 6.95 (95% CI = 1.77–27.37) P = 0.006] number of ART regimens failed before DAAs initiation [aHR (per more regimen) = 1.22 (95% CI = 1.04–1.42), P = 0.012] and age [aHR (per year older) = 1.16 (95% CI = 1.04–1.29), P = 0.010]. CONCLUSIONS: Our findings underline the importance for close monitoring HIV-VL in selected patients. Whether this phenomenon is triggered by the rapid clearance of HCV remains to be established. |
format | Online Article Text |
id | pubmed-8812874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-88128742022-02-04 Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV Morsica, Giulia Galli, Laura Messina, Emanuela Castagna, Antonella Bagaglio, Sabrina Salpietro, Stefania Liviana, Della Torre Uberti-Foppa, Caterina Hasson, Hamid PLoS One Research Article BACKGROUND: The dynamic of HIV-viral load (VL) remains poorly investigated in HIV/HCV patients under direct acting antivirals (DAAs). METHODS: We retrospectively evaluated HIV-VL at baseline (BL) during and up to 24 weeks post-DAAs in a cohort of 305 HIV-1/HCV patients, on ART and with no HIV virological failure (VF) in the 6 months before treatment with DAAs; during the period of observation VF was defined as confirmed VL≥50 copies/mL; virological blips (VB, transient, not confirmed, VL ≥50 copies/mL). Stepwise Cox regression models were fitted to estimate adjusted hazard ratios (aHR) of VF. RESULTS: Fifteen VF occurred in 13 patients over 187 person-years of follow-up (PYFU): incidence rate (IR) of 8.0 per 100-PYFU (95% CI = 4.0–12.1); 29 VBs were detected in 26 patients over 184 PYFU: IR = 15.8 per 100-PYFU (95% CI = 10.0–21.5). The most prominent factor associated with VF was the presence of BL HIV residual viremia (RV = HIV-RNA detectable but not precisely quantifiable) [aHR = 12.26 (95% CI = 3.74–40.17), P<0.0001]. Other factors were ≥1 VBs in the 6 months before DAAs [aHR = 6.95 (95% CI = 1.77–27.37) P = 0.006] number of ART regimens failed before DAAs initiation [aHR (per more regimen) = 1.22 (95% CI = 1.04–1.42), P = 0.012] and age [aHR (per year older) = 1.16 (95% CI = 1.04–1.29), P = 0.010]. CONCLUSIONS: Our findings underline the importance for close monitoring HIV-VL in selected patients. Whether this phenomenon is triggered by the rapid clearance of HCV remains to be established. Public Library of Science 2022-02-03 /pmc/articles/PMC8812874/ /pubmed/35113890 http://dx.doi.org/10.1371/journal.pone.0262917 Text en © 2022 Morsica et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Morsica, Giulia Galli, Laura Messina, Emanuela Castagna, Antonella Bagaglio, Sabrina Salpietro, Stefania Liviana, Della Torre Uberti-Foppa, Caterina Hasson, Hamid Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV |
title | Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV |
title_full | Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV |
title_fullStr | Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV |
title_full_unstemmed | Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV |
title_short | Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV |
title_sort | risk of hiv viral rebound in hiv infected patients on direct acting antivirals (daas) treatment for hcv |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812874/ https://www.ncbi.nlm.nih.gov/pubmed/35113890 http://dx.doi.org/10.1371/journal.pone.0262917 |
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