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Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study

Idiopathic pulmonary fibrosis (IPF), a fibrosing interstitial lung disease, predominantly affects the elderly and is associated with a high mortality risk. Nintedanib, a tyrosine kinase inhibitor, significantly reduces IPF progression. However, data on the tolerability and efficacy of nintedanib in...

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Autores principales: Komatsu, Masamichi, Yamamoto, Hiroshi, Ichiyama, Takashi, Kawakami, Satoshi, Uehara, Takeshi, Yoshikawa, Yumi, Kitaguchi, Yoshiaki, Ushiki, Atsuhito, Yasuo, Masanori, Hanaoka, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812933/
https://www.ncbi.nlm.nih.gov/pubmed/35113907
http://dx.doi.org/10.1371/journal.pone.0262795
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author Komatsu, Masamichi
Yamamoto, Hiroshi
Ichiyama, Takashi
Kawakami, Satoshi
Uehara, Takeshi
Yoshikawa, Yumi
Kitaguchi, Yoshiaki
Ushiki, Atsuhito
Yasuo, Masanori
Hanaoka, Masayuki
author_facet Komatsu, Masamichi
Yamamoto, Hiroshi
Ichiyama, Takashi
Kawakami, Satoshi
Uehara, Takeshi
Yoshikawa, Yumi
Kitaguchi, Yoshiaki
Ushiki, Atsuhito
Yasuo, Masanori
Hanaoka, Masayuki
author_sort Komatsu, Masamichi
collection PubMed
description Idiopathic pulmonary fibrosis (IPF), a fibrosing interstitial lung disease, predominantly affects the elderly and is associated with a high mortality risk. Nintedanib, a tyrosine kinase inhibitor, significantly reduces IPF progression. However, data on the tolerability and efficacy of nintedanib in the elderly with IPF are limited. Therefore, this study aimed to examine the tolerability and efficacy of nintedanib in the elderly with IPF in a real-world setting. Medical records of 19 elderly IPF patients (≥ 75 years) and 46 non-elderly IPF patients (< 75 years) newly administered nintedanib were retrospectively analyzed. We compared the forced vital capacity (FVC) level, incidence and severity of adverse events, and continuation rates of nintedanib between the two groups. FVC and percent predicted diffusing capacity of the lung for carbon monoxide (DLco) were lower in the elderly IPF group at baseline. Although the elderly IPF patients had a significantly higher incidence of adverse events, such as diarrhea, nausea, and elevation of hepatic enzymes, the rate of discontinuation of nintedanib owing to adverse events was not different between the groups. The continuation rates of nintedanib treatment at 6 months and 1 year in the elderly IPF group were equivalent. Furthermore, there was a similar trend in the reduction of the annual FVC decline after nintedanib initiation between the groups. Our study demonstrated that nintedanib was tolerable in both the IPF patient groups in a real-world setting. Proper management of adverse events in the elderly with IPF would lead to a better clinical outcome.
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spelling pubmed-88129332022-02-04 Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study Komatsu, Masamichi Yamamoto, Hiroshi Ichiyama, Takashi Kawakami, Satoshi Uehara, Takeshi Yoshikawa, Yumi Kitaguchi, Yoshiaki Ushiki, Atsuhito Yasuo, Masanori Hanaoka, Masayuki PLoS One Research Article Idiopathic pulmonary fibrosis (IPF), a fibrosing interstitial lung disease, predominantly affects the elderly and is associated with a high mortality risk. Nintedanib, a tyrosine kinase inhibitor, significantly reduces IPF progression. However, data on the tolerability and efficacy of nintedanib in the elderly with IPF are limited. Therefore, this study aimed to examine the tolerability and efficacy of nintedanib in the elderly with IPF in a real-world setting. Medical records of 19 elderly IPF patients (≥ 75 years) and 46 non-elderly IPF patients (< 75 years) newly administered nintedanib were retrospectively analyzed. We compared the forced vital capacity (FVC) level, incidence and severity of adverse events, and continuation rates of nintedanib between the two groups. FVC and percent predicted diffusing capacity of the lung for carbon monoxide (DLco) were lower in the elderly IPF group at baseline. Although the elderly IPF patients had a significantly higher incidence of adverse events, such as diarrhea, nausea, and elevation of hepatic enzymes, the rate of discontinuation of nintedanib owing to adverse events was not different between the groups. The continuation rates of nintedanib treatment at 6 months and 1 year in the elderly IPF group were equivalent. Furthermore, there was a similar trend in the reduction of the annual FVC decline after nintedanib initiation between the groups. Our study demonstrated that nintedanib was tolerable in both the IPF patient groups in a real-world setting. Proper management of adverse events in the elderly with IPF would lead to a better clinical outcome. Public Library of Science 2022-02-03 /pmc/articles/PMC8812933/ /pubmed/35113907 http://dx.doi.org/10.1371/journal.pone.0262795 Text en © 2022 Komatsu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Komatsu, Masamichi
Yamamoto, Hiroshi
Ichiyama, Takashi
Kawakami, Satoshi
Uehara, Takeshi
Yoshikawa, Yumi
Kitaguchi, Yoshiaki
Ushiki, Atsuhito
Yasuo, Masanori
Hanaoka, Masayuki
Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study
title Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study
title_full Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study
title_fullStr Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study
title_full_unstemmed Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study
title_short Tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: A single-center retrospective study
title_sort tolerability of nintedanib in the elderly with idiopathic pulmonary fibrosis: a single-center retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812933/
https://www.ncbi.nlm.nih.gov/pubmed/35113907
http://dx.doi.org/10.1371/journal.pone.0262795
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