Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO) pathway protects mice against the metabolic...

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Detalles Bibliográficos
Autores principales: Schugar, Rebecca C, Gliniak, Christy M, Osborn, Lucas J, Massey, William, Sangwan, Naseer, Horak, Anthony, Banerjee, Rakhee, Orabi, Danny, Helsley, Robert N, Brown, Amanda L, Burrows, Amy, Finney, Chelsea, Fung, Kevin K, Allen, Frederick M, Ferguson, Daniel, Gromovsky, Anthony D, Neumann, Chase, Cook, Kendall, McMillan, Amy, Buffa, Jennifer A, Anderson, James T, Mehrabian, Margarete, Goudarzi, Maryam, Willard, Belinda, Mak, Tytus D, Armstrong, Andrew R, Swanson, Garth, Keshavarzian, Ali, Garcia-Garcia, Jose Carlos, Wang, Zeneng, Lusis, Aldons J, Hazen, Stanley L, Brown, Jonathan Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813054/
https://www.ncbi.nlm.nih.gov/pubmed/35072627
http://dx.doi.org/10.7554/eLife.63998

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