Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling

Integrins are cellular receptors that regulate cell adhesion and many other cellular functions. Integrins can be activated via an “inside-out pathway” that is promoted by RAP1 GTPase. RAP1-GTP-Interacting Adaptor Molecular (RIAM) mediates integrin activation by linking RAP1 GTPase to talin, an integ...

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Detalles Bibliográficos
Autores principales: Su, Baihao, Wu, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813058/
https://www.ncbi.nlm.nih.gov/pubmed/35128538
http://dx.doi.org/10.33696/signaling.2.041
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author Su, Baihao
Wu, Jinhua
author_facet Su, Baihao
Wu, Jinhua
author_sort Su, Baihao
collection PubMed
description Integrins are cellular receptors that regulate cell adhesion and many other cellular functions. Integrins can be activated via an “inside-out pathway” that is promoted by RAP1 GTPase. RAP1-GTP-Interacting Adaptor Molecular (RIAM) mediates integrin activation by linking RAP1 GTPase to talin, an integrin activator. RIAM’s function in integrin signaling is tightly regulated. In this commentary, we review recent studies of the molecular mechanisms underlying RIAM autoinhibition via both intramolecular interaction and oligomer assembly, and the phosphorylation-dependent activation of RIAM.
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spelling pubmed-88130582022-02-03 Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling Su, Baihao Wu, Jinhua J Cell Signal Article Integrins are cellular receptors that regulate cell adhesion and many other cellular functions. Integrins can be activated via an “inside-out pathway” that is promoted by RAP1 GTPase. RAP1-GTP-Interacting Adaptor Molecular (RIAM) mediates integrin activation by linking RAP1 GTPase to talin, an integrin activator. RIAM’s function in integrin signaling is tightly regulated. In this commentary, we review recent studies of the molecular mechanisms underlying RIAM autoinhibition via both intramolecular interaction and oligomer assembly, and the phosphorylation-dependent activation of RIAM. 2021 /pmc/articles/PMC8813058/ /pubmed/35128538 http://dx.doi.org/10.33696/signaling.2.041 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Su, Baihao
Wu, Jinhua
Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling
title Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling
title_full Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling
title_fullStr Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling
title_full_unstemmed Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling
title_short Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling
title_sort phosphorylation of riam activates its adaptor function in mediating integrin signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813058/
https://www.ncbi.nlm.nih.gov/pubmed/35128538
http://dx.doi.org/10.33696/signaling.2.041
work_keys_str_mv AT subaihao phosphorylationofriamactivatesitsadaptorfunctioninmediatingintegrinsignaling
AT wujinhua phosphorylationofriamactivatesitsadaptorfunctioninmediatingintegrinsignaling

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