Exposure to extracellular vesicles from Pseudomonas aeruginosa result in loss of DNA methylation at enhancer and DNase hypersensitive site regions in lung macrophages

Various pathogens use differing strategies to evade host immune response including modulating the host’s epigenome. Here, we investigate if EVs secreted from P. aeruginosa alter DNA methylation in human lung macrophages, thereby potentially contributing to a dysfunctional innate immune response. Usi...

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Detalles Bibliográficos
Autores principales: Kyung Lee, Min, Armstrong, David A., Hazlett, Haley F., Dessaint, John A., Mellinger, Diane L., Aridgides, Daniel. S., Christensen, Brock C., Ashare, Alix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813072/
https://www.ncbi.nlm.nih.gov/pubmed/33380271
http://dx.doi.org/10.1080/15592294.2020.1853318

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