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Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage

Coronavirus disease 2019 (COVID-19) has become a worldwide public health emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns. Efficient disinfection methods are crucial for the prevention of viral transmission. Herein, pulse power-driven cold atmospheric plasma (C...

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Detalles Bibliográficos
Autores principales: Qin, Hongbo, Qiu, Hengju, He, Shi-Ting, Hong, Bixia, Liu, Ke, Lou, Fuxing, Li, Maochen, Hu, Pan, Kong, Xianghao, Song, Yujie, Liu, Yuchen, Pu, Mingfang, Han, Pengjun, Li, Mengzhe, An, Xiaoping, Song, Lihua, Tong, Yigang, Fan, Huahao, Wang, Ruixue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813208/
https://www.ncbi.nlm.nih.gov/pubmed/35149493
http://dx.doi.org/10.1016/j.jhazmat.2022.128414
Descripción
Sumario:Coronavirus disease 2019 (COVID-19) has become a worldwide public health emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns. Efficient disinfection methods are crucial for the prevention of viral transmission. Herein, pulse power-driven cold atmospheric plasma (CAP), a novel sterilization strategy, was found to potently inactivate SARS-CoV-2-like coronavirus GX_P2V, six strains of major epidemic SARS-CoV-2 variants and even swine coronavirus PEDV and SADS-CoV within 300 s (with inhibition rate more than 99%). We identified four dominant short-lived reactive species, ONOO(-), (1)O(2), O(2)(-) and·OH, generated in response to CAP and distinguished their roles in the inactivation of GX_P2V and SARS-CoV-2 spike protein receptor binding domain (RBD), which is responsible for recognition and binding to human angiotensin-converting enzyme 2 (hACE2). Our study provides detailed evidence of a novel surface disinfection strategy for SARS-CoV-2 and other coronaviruses.