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Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage

Coronavirus disease 2019 (COVID-19) has become a worldwide public health emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns. Efficient disinfection methods are crucial for the prevention of viral transmission. Herein, pulse power-driven cold atmospheric plasma (C...

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Autores principales: Qin, Hongbo, Qiu, Hengju, He, Shi-Ting, Hong, Bixia, Liu, Ke, Lou, Fuxing, Li, Maochen, Hu, Pan, Kong, Xianghao, Song, Yujie, Liu, Yuchen, Pu, Mingfang, Han, Pengjun, Li, Mengzhe, An, Xiaoping, Song, Lihua, Tong, Yigang, Fan, Huahao, Wang, Ruixue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813208/
https://www.ncbi.nlm.nih.gov/pubmed/35149493
http://dx.doi.org/10.1016/j.jhazmat.2022.128414
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author Qin, Hongbo
Qiu, Hengju
He, Shi-Ting
Hong, Bixia
Liu, Ke
Lou, Fuxing
Li, Maochen
Hu, Pan
Kong, Xianghao
Song, Yujie
Liu, Yuchen
Pu, Mingfang
Han, Pengjun
Li, Mengzhe
An, Xiaoping
Song, Lihua
Tong, Yigang
Fan, Huahao
Wang, Ruixue
author_facet Qin, Hongbo
Qiu, Hengju
He, Shi-Ting
Hong, Bixia
Liu, Ke
Lou, Fuxing
Li, Maochen
Hu, Pan
Kong, Xianghao
Song, Yujie
Liu, Yuchen
Pu, Mingfang
Han, Pengjun
Li, Mengzhe
An, Xiaoping
Song, Lihua
Tong, Yigang
Fan, Huahao
Wang, Ruixue
author_sort Qin, Hongbo
collection PubMed
description Coronavirus disease 2019 (COVID-19) has become a worldwide public health emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns. Efficient disinfection methods are crucial for the prevention of viral transmission. Herein, pulse power-driven cold atmospheric plasma (CAP), a novel sterilization strategy, was found to potently inactivate SARS-CoV-2-like coronavirus GX_P2V, six strains of major epidemic SARS-CoV-2 variants and even swine coronavirus PEDV and SADS-CoV within 300 s (with inhibition rate more than 99%). We identified four dominant short-lived reactive species, ONOO(-), (1)O(2), O(2)(-) and·OH, generated in response to CAP and distinguished their roles in the inactivation of GX_P2V and SARS-CoV-2 spike protein receptor binding domain (RBD), which is responsible for recognition and binding to human angiotensin-converting enzyme 2 (hACE2). Our study provides detailed evidence of a novel surface disinfection strategy for SARS-CoV-2 and other coronaviruses.
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spelling pubmed-88132082022-02-04 Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage Qin, Hongbo Qiu, Hengju He, Shi-Ting Hong, Bixia Liu, Ke Lou, Fuxing Li, Maochen Hu, Pan Kong, Xianghao Song, Yujie Liu, Yuchen Pu, Mingfang Han, Pengjun Li, Mengzhe An, Xiaoping Song, Lihua Tong, Yigang Fan, Huahao Wang, Ruixue J Hazard Mater Research Paper Coronavirus disease 2019 (COVID-19) has become a worldwide public health emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns. Efficient disinfection methods are crucial for the prevention of viral transmission. Herein, pulse power-driven cold atmospheric plasma (CAP), a novel sterilization strategy, was found to potently inactivate SARS-CoV-2-like coronavirus GX_P2V, six strains of major epidemic SARS-CoV-2 variants and even swine coronavirus PEDV and SADS-CoV within 300 s (with inhibition rate more than 99%). We identified four dominant short-lived reactive species, ONOO(-), (1)O(2), O(2)(-) and·OH, generated in response to CAP and distinguished their roles in the inactivation of GX_P2V and SARS-CoV-2 spike protein receptor binding domain (RBD), which is responsible for recognition and binding to human angiotensin-converting enzyme 2 (hACE2). Our study provides detailed evidence of a novel surface disinfection strategy for SARS-CoV-2 and other coronaviruses. Elsevier B.V. 2022-05-15 2022-02-04 /pmc/articles/PMC8813208/ /pubmed/35149493 http://dx.doi.org/10.1016/j.jhazmat.2022.128414 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Paper
Qin, Hongbo
Qiu, Hengju
He, Shi-Ting
Hong, Bixia
Liu, Ke
Lou, Fuxing
Li, Maochen
Hu, Pan
Kong, Xianghao
Song, Yujie
Liu, Yuchen
Pu, Mingfang
Han, Pengjun
Li, Mengzhe
An, Xiaoping
Song, Lihua
Tong, Yigang
Fan, Huahao
Wang, Ruixue
Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
title Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
title_full Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
title_fullStr Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
title_full_unstemmed Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
title_short Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
title_sort efficient disinfection of sars-cov-2-like coronavirus, pseudotyped sars-cov-2 and other coronaviruses using cold plasma induces spike protein damage
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813208/
https://www.ncbi.nlm.nih.gov/pubmed/35149493
http://dx.doi.org/10.1016/j.jhazmat.2022.128414
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