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Four-Octyl Itaconate Protects Chondrocytes against H(2)O(2)-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling

Nrf2 is a critical regulator of the antioxidant defense systems in cellular protection. Emerging evidence has shown that four-octyl itaconate (OI) activates Nrf2 cascade. In this study, the chondroprotective effects of OI on H(2)O(2)-stimulated chondrocytes and DMM-induced osteoarthritis (OA) progre...

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Detalles Bibliográficos
Autores principales:	Zhang, Peng, Wang, Xiaotong, Peng, Qiliang, Jin, Yesheng, Shi, Gaolong, Fan, Zhihai, Zhou, Zhiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813279/ https://www.ncbi.nlm.nih.gov/pubmed/35126808 http://dx.doi.org/10.1155/2022/2206167

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