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Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta
Alzheimer’s disease (AD) is the most common cause of neurodegeneration. It is characterized by deposits of amyloid beta (Aβ) plaques and impaired memory. Microglia are associated with AD. They are activated in the AD brain and AD models. However, the exact role of microglia has not been established....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Chonnam National University Medical School
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813657/ https://www.ncbi.nlm.nih.gov/pubmed/35169554 http://dx.doi.org/10.4068/cmj.2022.58.1.13 |
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author | Lee, Sunjun Choi, Won-Seok |
author_facet | Lee, Sunjun Choi, Won-Seok |
author_sort | Lee, Sunjun |
collection | PubMed |
description | Alzheimer’s disease (AD) is the most common cause of neurodegeneration. It is characterized by deposits of amyloid beta (Aβ) plaques and impaired memory. Microglia are associated with AD. They are activated in the AD brain and AD models. However, the exact role of microglia has not been established. We thus investigated the role of microglia in AD models using a primary culture and an ex-vivo assay. We showed that oligomerized Aβ is toxic to neurons in the primary culture. In the ex-vivo assay, a microglial cell line removed amyloid plaques in the brain of 5XFAD (AD model) mice. To verify if microglia can be protective for the neuron, we co-cultured neurons with primary microglia and treated them with Aβ. The loss of neurons, induced by amyloid toxicity, was attenuated by co-cultured microglia. Taken together, our data suggest that microglia promote neuronal survival by phagocytic clearance of Aβ in AD models. |
format | Online Article Text |
id | pubmed-8813657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Chonnam National University Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-88136572022-02-14 Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta Lee, Sunjun Choi, Won-Seok Chonnam Med J Original Article Alzheimer’s disease (AD) is the most common cause of neurodegeneration. It is characterized by deposits of amyloid beta (Aβ) plaques and impaired memory. Microglia are associated with AD. They are activated in the AD brain and AD models. However, the exact role of microglia has not been established. We thus investigated the role of microglia in AD models using a primary culture and an ex-vivo assay. We showed that oligomerized Aβ is toxic to neurons in the primary culture. In the ex-vivo assay, a microglial cell line removed amyloid plaques in the brain of 5XFAD (AD model) mice. To verify if microglia can be protective for the neuron, we co-cultured neurons with primary microglia and treated them with Aβ. The loss of neurons, induced by amyloid toxicity, was attenuated by co-cultured microglia. Taken together, our data suggest that microglia promote neuronal survival by phagocytic clearance of Aβ in AD models. Chonnam National University Medical School 2022-01 2022-01-25 /pmc/articles/PMC8813657/ /pubmed/35169554 http://dx.doi.org/10.4068/cmj.2022.58.1.13 Text en © Chonnam Medical Journal, 2022 https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Sunjun Choi, Won-Seok Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta |
title | Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta |
title_full | Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta |
title_fullStr | Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta |
title_full_unstemmed | Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta |
title_short | Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta |
title_sort | protective role of microglia on neuronal survival after exposure to amyloid beta |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813657/ https://www.ncbi.nlm.nih.gov/pubmed/35169554 http://dx.doi.org/10.4068/cmj.2022.58.1.13 |
work_keys_str_mv | AT leesunjun protectiveroleofmicrogliaonneuronalsurvivalafterexposuretoamyloidbeta AT choiwonseok protectiveroleofmicrogliaonneuronalsurvivalafterexposuretoamyloidbeta |