Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression

We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring’s autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associat...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xian, Zou, Mingyang, Sun, Caihong, Wu, Lijie, Chen, Wen-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813730/
https://www.ncbi.nlm.nih.gov/pubmed/33743119
http://dx.doi.org/10.1007/s10803-021-04951-8
_version_ 1784644924847685632
author Liu, Xian
Zou, Mingyang
Sun, Caihong
Wu, Lijie
Chen, Wen-Xiong
author_facet Liu, Xian
Zou, Mingyang
Sun, Caihong
Wu, Lijie
Chen, Wen-Xiong
author_sort Liu, Xian
collection PubMed
description We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring’s autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring’s ASD [OR 0.57, 95% CI 0.41–0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36–0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring’s ASD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10803-021-04951-8.
format Online
Article
Text
id pubmed-8813730
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-88137302022-02-11 Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression Liu, Xian Zou, Mingyang Sun, Caihong Wu, Lijie Chen, Wen-Xiong J Autism Dev Disord Original Paper We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring’s autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring’s ASD [OR 0.57, 95% CI 0.41–0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36–0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring’s ASD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10803-021-04951-8. Springer US 2021-03-20 2022 /pmc/articles/PMC8813730/ /pubmed/33743119 http://dx.doi.org/10.1007/s10803-021-04951-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Liu, Xian
Zou, Mingyang
Sun, Caihong
Wu, Lijie
Chen, Wen-Xiong
Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression
title Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression
title_full Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression
title_fullStr Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression
title_full_unstemmed Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression
title_short Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression
title_sort prenatal folic acid supplements and offspring’s autism spectrum disorder: a meta-analysis and meta-regression
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813730/
https://www.ncbi.nlm.nih.gov/pubmed/33743119
http://dx.doi.org/10.1007/s10803-021-04951-8
work_keys_str_mv AT liuxian prenatalfolicacidsupplementsandoffspringsautismspectrumdisorderametaanalysisandmetaregression
AT zoumingyang prenatalfolicacidsupplementsandoffspringsautismspectrumdisorderametaanalysisandmetaregression
AT suncaihong prenatalfolicacidsupplementsandoffspringsautismspectrumdisorderametaanalysisandmetaregression
AT wulijie prenatalfolicacidsupplementsandoffspringsautismspectrumdisorderametaanalysisandmetaregression
AT chenwenxiong prenatalfolicacidsupplementsandoffspringsautismspectrumdisorderametaanalysisandmetaregression

Ejemplares similares