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The Role of Circulating Biomarkers in Lung Cancer
Lung cancer is the leading cause of cancer morbidity and mortality worldwide and early diagnosis is crucial for the management and treatment of this disease. Non-invasive means of determining tumour information is an appealing diagnostic approach for lung cancers as often accessing and removing tumo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813755/ https://www.ncbi.nlm.nih.gov/pubmed/35127511 http://dx.doi.org/10.3389/fonc.2021.801269 |
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author | Herath, Sayuri Sadeghi Rad, Habib Radfar, Payar Ladwa, Rahul Warkiani, Majid O’Byrne, Ken Kulasinghe, Arutha |
author_facet | Herath, Sayuri Sadeghi Rad, Habib Radfar, Payar Ladwa, Rahul Warkiani, Majid O’Byrne, Ken Kulasinghe, Arutha |
author_sort | Herath, Sayuri |
collection | PubMed |
description | Lung cancer is the leading cause of cancer morbidity and mortality worldwide and early diagnosis is crucial for the management and treatment of this disease. Non-invasive means of determining tumour information is an appealing diagnostic approach for lung cancers as often accessing and removing tumour tissue can be a limiting factor. In recent years, liquid biopsies have been developed to explore potential circulating tumour biomarkers which are considered reliable surrogates for understanding tumour biology in a non-invasive manner. Most common components assessed in liquid biopsy include circulating tumour cells (CTCs), cell-free DNA (cfDNA), circulating tumour DNA (ctDNA), microRNA and exosomes. This review explores the clinical use of circulating tumour biomarkers found in liquid biopsy for screening, early diagnosis and prognostication of lung cancer patients. |
format | Online Article Text |
id | pubmed-8813755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88137552022-02-05 The Role of Circulating Biomarkers in Lung Cancer Herath, Sayuri Sadeghi Rad, Habib Radfar, Payar Ladwa, Rahul Warkiani, Majid O’Byrne, Ken Kulasinghe, Arutha Front Oncol Oncology Lung cancer is the leading cause of cancer morbidity and mortality worldwide and early diagnosis is crucial for the management and treatment of this disease. Non-invasive means of determining tumour information is an appealing diagnostic approach for lung cancers as often accessing and removing tumour tissue can be a limiting factor. In recent years, liquid biopsies have been developed to explore potential circulating tumour biomarkers which are considered reliable surrogates for understanding tumour biology in a non-invasive manner. Most common components assessed in liquid biopsy include circulating tumour cells (CTCs), cell-free DNA (cfDNA), circulating tumour DNA (ctDNA), microRNA and exosomes. This review explores the clinical use of circulating tumour biomarkers found in liquid biopsy for screening, early diagnosis and prognostication of lung cancer patients. Frontiers Media S.A. 2022-01-21 /pmc/articles/PMC8813755/ /pubmed/35127511 http://dx.doi.org/10.3389/fonc.2021.801269 Text en Copyright © 2022 Herath, Sadeghi Rad, Radfar, Ladwa, Warkiani, O’Byrne and Kulasinghe https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Herath, Sayuri Sadeghi Rad, Habib Radfar, Payar Ladwa, Rahul Warkiani, Majid O’Byrne, Ken Kulasinghe, Arutha The Role of Circulating Biomarkers in Lung Cancer |
title | The Role of Circulating Biomarkers in Lung Cancer |
title_full | The Role of Circulating Biomarkers in Lung Cancer |
title_fullStr | The Role of Circulating Biomarkers in Lung Cancer |
title_full_unstemmed | The Role of Circulating Biomarkers in Lung Cancer |
title_short | The Role of Circulating Biomarkers in Lung Cancer |
title_sort | role of circulating biomarkers in lung cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813755/ https://www.ncbi.nlm.nih.gov/pubmed/35127511 http://dx.doi.org/10.3389/fonc.2021.801269 |
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