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Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China

OBJECTIVE: The purpose of this study is to describe the current clinical situation of patients with painful diabetic peripheral neuropathy (DPN) and related anxiety, depression, and the quality of life of patients in mainland China, and to report the current status of the use of analgesics. METHODS:...

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Autores principales: Lian, Jingxuan, Wang, Haijun, Cui, Rongrong, Zhang, Chaoxia, Fu, Jianfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813762/
https://www.ncbi.nlm.nih.gov/pubmed/35126315
http://dx.doi.org/10.3389/fendo.2021.813210
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author Lian, Jingxuan
Wang, Haijun
Cui, Rongrong
Zhang, Chaoxia
Fu, Jianfang
author_facet Lian, Jingxuan
Wang, Haijun
Cui, Rongrong
Zhang, Chaoxia
Fu, Jianfang
author_sort Lian, Jingxuan
collection PubMed
description OBJECTIVE: The purpose of this study is to describe the current clinical situation of patients with painful diabetic peripheral neuropathy (DPN) and related anxiety, depression, and the quality of life of patients in mainland China, and to report the current status of the use of analgesics. METHODS: Between June 15, 2021, and October 15, 2021, a total of 401 participants participated in the study. Recruitment was carried out using a multi-level sampling method. Participants’ demographics, medical history, analgesic use, Michigan Symptom Score (MNSI), Numerical Rating Scale (NRS) pain score, Patient Health Questionnaire 9 (PHQ-9) score, Generalized Anxiety Disorder 7 (GAD) -7) Score, quality of life score (SF-12) and diabetes treatment status were collected. RESULTS: Among the participants, there were 236 male patients and female patients. Participants were 322 patients over 40 years old. Regarding the use of analgesics: 132 patients reported using analgesics, 221 patients reported not using analgesics, and 48 patients reported having used analgesics. The results of the scale showed that the scores of NRS, GAD-7, PHQ-9 and SF-12 were 5.12 ± 2.15, 6.33 ± 3.67, 8.46 ± 4.07 and 47.84 ± 19.92 for patients who used analgesics, Compared with patients who did not use analgesics (NRS: 1.99 ± 1.7, GAD-7: 1.81 ± 2.81, PHQ-9: 3.13 ± 4.10, SF-12: 78.34 ± 21.66) there are significant differences (p< 0.001). In addition, patients’ NRS scores are also closely related to GAD-7, PHQ-9 and SF-12 scores. CONCLUSION: The severity of symptoms, mental status and quality of life of patients who used analgesics were more severe than those of patients who did not use analgesics. Pregabalin is still the preferred analgesic for patients with painful DPN, and the use of opioids in my country is extremely low, which is consistent with current international guidelines. Age, diabetic duration, DPN duration, PHQ-9 score, GAD-7 score and SF-12 scores are closely related to NRS pain scores. In addition, there are still a considerable number of patients who have not used analgesics due to financial burdens and other reasons, suggesting that China still has insufficient pain management in DPN patients.
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spelling pubmed-88137622022-02-05 Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China Lian, Jingxuan Wang, Haijun Cui, Rongrong Zhang, Chaoxia Fu, Jianfang Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: The purpose of this study is to describe the current clinical situation of patients with painful diabetic peripheral neuropathy (DPN) and related anxiety, depression, and the quality of life of patients in mainland China, and to report the current status of the use of analgesics. METHODS: Between June 15, 2021, and October 15, 2021, a total of 401 participants participated in the study. Recruitment was carried out using a multi-level sampling method. Participants’ demographics, medical history, analgesic use, Michigan Symptom Score (MNSI), Numerical Rating Scale (NRS) pain score, Patient Health Questionnaire 9 (PHQ-9) score, Generalized Anxiety Disorder 7 (GAD) -7) Score, quality of life score (SF-12) and diabetes treatment status were collected. RESULTS: Among the participants, there were 236 male patients and female patients. Participants were 322 patients over 40 years old. Regarding the use of analgesics: 132 patients reported using analgesics, 221 patients reported not using analgesics, and 48 patients reported having used analgesics. The results of the scale showed that the scores of NRS, GAD-7, PHQ-9 and SF-12 were 5.12 ± 2.15, 6.33 ± 3.67, 8.46 ± 4.07 and 47.84 ± 19.92 for patients who used analgesics, Compared with patients who did not use analgesics (NRS: 1.99 ± 1.7, GAD-7: 1.81 ± 2.81, PHQ-9: 3.13 ± 4.10, SF-12: 78.34 ± 21.66) there are significant differences (p< 0.001). In addition, patients’ NRS scores are also closely related to GAD-7, PHQ-9 and SF-12 scores. CONCLUSION: The severity of symptoms, mental status and quality of life of patients who used analgesics were more severe than those of patients who did not use analgesics. Pregabalin is still the preferred analgesic for patients with painful DPN, and the use of opioids in my country is extremely low, which is consistent with current international guidelines. Age, diabetic duration, DPN duration, PHQ-9 score, GAD-7 score and SF-12 scores are closely related to NRS pain scores. In addition, there are still a considerable number of patients who have not used analgesics due to financial burdens and other reasons, suggesting that China still has insufficient pain management in DPN patients. Frontiers Media S.A. 2022-01-21 /pmc/articles/PMC8813762/ /pubmed/35126315 http://dx.doi.org/10.3389/fendo.2021.813210 Text en Copyright © 2022 Lian, Wang, Cui, Zhang and Fu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Lian, Jingxuan
Wang, Haijun
Cui, Rongrong
Zhang, Chaoxia
Fu, Jianfang
Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China
title Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China
title_full Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China
title_fullStr Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China
title_full_unstemmed Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China
title_short Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China
title_sort status of analgesic drugs and quality of life results for diabetic peripheral neuropathy in china
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813762/
https://www.ncbi.nlm.nih.gov/pubmed/35126315
http://dx.doi.org/10.3389/fendo.2021.813210
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