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Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation
Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO(2)) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to glomerulonephritis. These responses are suppres...
Autores principales: | Rajasinghe, Lichchavi D., Bates, Melissa A., Benninghoff, Abby D., Wierenga, Kathryn A., Harkema, Jack R., Pestka, James J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813772/ https://www.ncbi.nlm.nih.gov/pubmed/35126352 http://dx.doi.org/10.3389/fimmu.2021.781446 |
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