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Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates

BACKGROUND: Allopurinol, an xanthine oxidase (XO) inhibitor, is a promising intervention that may provide neuroprotection for neonates with hypoxic-ischemic encephalopathy (HIE). Currently, a double-blind, placebo-controlled study (ALBINO, NCT03162653) is investigating the neuroprotective effect of...

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Detalles Bibliográficos
Autores principales:	Chu, Wan-Yu, Annink, Kim V., Nijstad, A. Laura, Maiwald, Christian A., Schroth, Michael, Bakkali, Loubna el, van Bel, Frank, Benders, Manon J. N. L., van Weissenbruch, Mirjam M., Hagen, Anja, Franz, Axel R., Dorlo, Thomas P. C., Allegaert, Karel, Huitema, Alwin D. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813842/ https://www.ncbi.nlm.nih.gov/pubmed/34617261 http://dx.doi.org/10.1007/s40262-021-01068-0

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