Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling

Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signalling, endothelial cell dys...

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Detalles Bibliográficos
Autores principales: Kurakula, Kondababu, Hagdorn, Quint A. J., van der Feen, Diederik E., Vonk Noordegraaf, Anton, ten Dijke, Peter, de Boer, Rudolf A., Bogaard, Harm Jan, Goumans, Marie José, Berger, Rolf M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813847/
https://www.ncbi.nlm.nih.gov/pubmed/34379232
http://dx.doi.org/10.1007/s10456-021-09812-7

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