Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division

DENR and MCTS1 have been identified as oncogenes in several different tumor entities. The heterodimeric DENR·MCTS1 protein complex promotes translation of mRNAs containing upstream Open Reading Frames (uORFs). We show here that DENR is phosphorylated on Serine 73 by Cyclin B/CDK1 and Cyclin A/CDK2 a...

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Detalles Bibliográficos
Autores principales: Clemm von Hohenberg, Katharina, Müller, Sandra, Schleich, Sibylle, Meister, Matthias, Bohlen, Jonathan, Hofmann, Thomas G., Teleman, Aurelio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813921/
https://www.ncbi.nlm.nih.gov/pubmed/35115540
http://dx.doi.org/10.1038/s41467-022-28265-0

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