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Carvedilol targets β-arrestins to rewire innate immunity and improve oncolytic adenoviral therapy

Oncolytic viruses are being tested in clinical trials, including in women with ovarian cancer. We use a drug-repurposing approach to identify existing drugs that enhance the activity of oncolytic adenoviruses. This reveals that carvedilol, a β-arrestin-biased β-blocker, synergises with both wild-typ...

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Detalles Bibliográficos
Autores principales:	Hoare, Joseph I., Osmani, Bleona, O’Sullivan, Emily A., Browne, Ashley, Campbell, Nicola, Metcalf, Stephen, Nicolini, Francesco, Saxena, Jayeta, Martin, Sarah A., Lockley, Michelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813932/ https://www.ncbi.nlm.nih.gov/pubmed/35115660 http://dx.doi.org/10.1038/s42003-022-03041-4

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