TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in the presence of reactive oxygen species (ROS) and elevated lipid oxidation. Here we show, usi...

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Detalles Bibliográficos
Autores principales: Wu, Jiao, Feng, Zhuan, Chen, Liang, Li, Yong, Bian, Huijie, Geng, Jiejie, Zheng, Zhao-Hui, Fu, Xianghui, Pei, Zhuo, Qin, Yifei, Yang, Liu, Zhao, Yilin, Wang, Ke, Chen, Ruo, He, Qian, Nan, Gang, Jiang, Xuejun, Chen, Zhi-Nan, Zhu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813949/
https://www.ncbi.nlm.nih.gov/pubmed/35115492
http://dx.doi.org/10.1038/s41467-021-27948-4

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