An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

Kinase signaling fuels growth of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet its role in leukemia initiation is unclear and has not been shown in primary human hematopoietic cells. We previously described activating mutations in interleukin-7 receptor alpha (IL7RA) in poor-prognosis...

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Detalles Bibliográficos
Autores principales: Geron, Ifat, Savino, Angela Maria, Fishman, Hila, Tal, Noa, Brown, John, Turati, Virginia A., James, Chela, Sarno, Jolanda, Hameiri-Grossman, Michal, Lee, Yu Nee, Rein, Avigail, Maniriho, Hillary, Birger, Yehudit, Zemlyansky, Anna, Muler, Inna, Davis, Kara L., Marcu-Malina, Victoria, Mattson, Nicole, Parnas, Oren, Wagener, Rabea, Fischer, Ute, Barata, João T., Jamieson, Catriona H. M., Müschen, Markus, Chen, Chun-Wei, Borkhardt, Arndt, Kirsch, Ilan Richard, Nagler, Arnon, Enver, Tariq, Izraeli, Shai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814001/
https://www.ncbi.nlm.nih.gov/pubmed/35115489
http://dx.doi.org/10.1038/s41467-022-28218-7

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