Cargando…

Therapeutic response to leflunomide in combo therapy and monotherapy is associated to serum teriflunomide (A77 1726) levels

There is a significant rate of therapeutic failure in rheumatoid arthritis (RA) patients treated with leflunomide (LEF). This study investigates the utility values of teriflunomide levels (A77 1726) in identifying RA patients who remained with moderate or severe disease activity after the treatment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fajardo-Robledo, Nicte S., Jacobo-Cuevas, Heriberto, Perez-Guerrero, Edsaul E., Corona-Sanchez, Esther G., Saldaña-Cruz, A. Miriam, Romero-Tejeda, Elba M., Rodriguez-Jimenez, N. Alejandra, Totsuka-Sutto, Sylvia E., Lopez-Roa, Rocio I., Ponce-Guarneros, Juan M., Alcaraz-Lopez, M. Fabiola, Cerpa-Cruz, Sergio, Muñoz-Valle, J. Francisco, Cardona-Muñoz, E. German, Gonzalez-Lopez, Laura, Gamez-Nava, Jorge I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814146/ https://www.ncbi.nlm.nih.gov/pubmed/35115601 http://dx.doi.org/10.1038/s41598-022-05644-7

Ejemplares similares

The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
por: Kirsch, Bernhard M, et al.
Publicado: (2005)

The active metabolite of leflunomide, A77-1726, increases proliferation of human synovial fibroblasts in presence of IL-1β
por: Magne, D, et al.
Publicado: (2004)

The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes
por: Palmer, Gaby, et al.
Publicado: (2004)

The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1
por: Moon, Su-Jin, et al.
Publicado: (2017)

The -174G/C Interleukin-6 Gene Promoter Polymorphism as a Genetic Marker of Differences in Therapeutic Response to Methotrexate and Leflunomide in Rheumatoid Arthritis
por: Ruiz-Padilla, A. J., et al.
Publicado: (2016)

Painful Small Fiber Neuropathy Associated With Teriflunomide: A Case Series and Literature Review Related to Teriflunomide and Leflunomide
por: Elrefaey, Ahmed, et al.
Publicado: (2023)

Selective Binding of Cyclodextrins with Leflunomide and Its Pharmacologically Active Metabolite Teriflunomide
por: Terekhova, Irina, et al.
Publicado: (2020)

Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation
por: Xu, Xiulong, et al.
Publicado: (2017)

On the interactions of leflunomide and teriflunomide within receptor cavity — NMR studies and energy calculations
por: Kujawski, Jacek, et al.
Publicado: (2015)

Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
por: Ramirez-Villafaña, Melissa, et al.
Publicado: (2020)

Risk Factors of Muscle Wasting in Women with Rheumatoid Arthritis: Relevance of the Persistent Failure of Conventional Combination Therapy
por: Gomez-Ramirez, Eli E., et al.
Publicado: (2022)

Anti-nucleosome antibodies increase the risk of renal relapse in a prospective cohort of patients with clinically inactive systemic lupus erythematosus
por: Rodriguez-Jimenez, Norma Alejandra, et al.
Publicado: (2020)

Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study
por: Gamez-Nava, Jorge Ivan, et al.
Publicado: (2020)

From Leflunomide to Teriflunomide: Drug Development and Immuno-suppressive Oral Drugs in the Treatment of Multiple Sclerosis
por: Aly, Lilian, et al.
Publicado: (2017)

Physiologically Based Pharmacokinetic Model for Prediction of Leflunomide and Teriflunomide: Should Consideration Be Given to Cannalicular Efflux Transporters?
por: Srinivas, NR
Publicado: (2015)

Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)-induced lymphoproliferative disease and lytic viral replication
por: Bilger, Andrea, et al.
Publicado: (2017)

Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review
por: Kaur, Hardeep, et al.
Publicado: (2021)

1726P Expanding the role of medical oncologist in the management of COVID-19
por: Ghiglione, L., et al.
Publicado: (2020)

Response to Physiologically Based Pharmacokinetic Model for Prediction of Leflunomide and Teriflunomide—Should Consideration Be Given to Cannalicular Efflux Transporters?
por: Hopkins, AM, et al.
Publicado: (2015)

Inhibition of porcine epidemic diarrhea virus (PEDV) replication by A77 1726 through targeting JAK and Src tyrosine kinases
por: Li, Xiaomei, et al.
Publicado: (2020)

1726. Patterns of Isavuconazole Use for Invasive Fungal Infections
por: Gow-Lee, Vanessa, et al.
Publicado: (2022)

Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell Proliferation and Cell Cycle Progress()()
por: Doscas, Michelle E., et al.
Publicado: (2014)

Serum irisin concentrations and osteoporotic vertebral fractures in women with rheumatoid arthritis: A cross-sectional study
por: Gamez-Nava, Jorge Ivan, et al.
Publicado: (2022)

Functional disability is related to serum chemerin levels in rheumatoid arthritis
por: Vazquez-Villegas, Maria Luisa, et al.
Publicado: (2021)

Combo Prospecting
por: Hughes, Tony
Publicado: (2018)

Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti-Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis
por: Gonzalez-Lopez, Laura, et al.
Publicado: (2014)

Antología del pensamiento feminista español, 1726-2011
Publicado: (2012)

Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis
por: Diaz-Rizo, Valeria, et al.
Publicado: (2017)

Low serum uromodulin levels and their association with lupus flares
por: David, Bonilla-Lara, et al.
Publicado: (2022)

Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates
por: Sun, Jing, et al.
Publicado: (2018)

Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients
por: Beltrán-Ramírez, Alberto, et al.
Publicado: (2022)

La crítica del galisismo en España (1726-1832)
por: Rubio, Antonio
Publicado: (1937)

Formation of multiple pulmonary nodules during treatment with leflunomide
por: Yoshikawa, Gilberto Toshikawa, et al.
Publicado: (2015)

PB1726: HEARING STATUS OF SURVIVORS OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
por: Mahfouz, Asmaa, et al.
Publicado: (2023)

REMISSION OF HEREDITARY ANGIOEDEMA ATTACKS ASSOCIATED WITH STARTING TERIFLUNOMIDE IN A PATIENT WITH MULTIPLE SCLEROSIS
por: Fernández Romero, Diego S., et al.
Publicado: (2023)

Theses of Those Who Have Graduated at the University of Edinburgh, from 1726 to 1823
Publicado: (1824)

Association of adipokines, interleukin-6, and tumor necrosis factor-α concentrations with clinical characteristics and presence of spinal syndesmophytes in patients with ankylosing spondylitis: A cross-sectional study
por: Gonzalez-Lopez, Laura, et al.
Publicado: (2017)

Assessment of Serum sRANKL, sRANKL/OPG Ratio, and Other Bone Turnover Markers with the Estimated 10-Year Risk of Major and Hip Osteoporotic Fractures in Rheumatoid Arthritis: A Cross-Sectional Study
por: Nava-Valdivia, C. A., et al.
Publicado: (2021)

Wastewater remediation via combo-technology
por: Dwevedi, Alka, et al.
Publicado: (2019)

Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases: Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing
por: Díaz-Toscano, Miriam Lizette, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_b1n7rd8h6lu0iem75rpd3k5pt6