Cargando…
AKR1C1/2 inhibition by MPA sensitizes platinum resistant ovarian cancer towards carboplatin
In recurrent epithelial ovarian cancer (EOC) most patients develop platinum-resistance. On molecular level the NRF2 pathway, a cellular defense mechanism against reactive oxygen species, is induced. In this study, we investigate AKR1C1/2, target of NRF2, in a well-established EOC collective by immun...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814148/ https://www.ncbi.nlm.nih.gov/pubmed/35115586 http://dx.doi.org/10.1038/s41598-022-05785-9 |