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AKR1C1/2 inhibition by MPA sensitizes platinum resistant ovarian cancer towards carboplatin

In recurrent epithelial ovarian cancer (EOC) most patients develop platinum-resistance. On molecular level the NRF2 pathway, a cellular defense mechanism against reactive oxygen species, is induced. In this study, we investigate AKR1C1/2, target of NRF2, in a well-established EOC collective by immun...

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Detalles Bibliográficos
Autores principales:	Badmann, Susann, Mayr, Doris, Schmoeckel, Elisa, Hester, Anna, Buschmann, Christina, Beyer, Susanne, Kolben, Thomas, Kraus, Fabian, Chelariu-Raicu, Anca, Burges, Alexander, Mahner, Sven, Jeschke, Udo, Trillsch, Fabian, Czogalla, Bastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814148/ https://www.ncbi.nlm.nih.gov/pubmed/35115586 http://dx.doi.org/10.1038/s41598-022-05785-9

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