Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position

In whole breast and regional nodal irradiation (WB + RNI), breathhold increases organ at risk (OAR) sparing. WB + RNI is usually performed in supine position, because positioning materials obstruct beam paths in prone position. Recent advancements allow prone WB + RNI (pWB + RNI) with increased spar...

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Autores principales: Deseyne, Pieter, Speleers, Bruno, Paelinck, Leen, De Gersem, Werner, De Neve, Wilfried, Schoepen, Max, Van Greveling, Annick, Van Hulle, Hans, Vakaet, Vincent, Post, Giselle, Monten, Chris, Depypere, Herman, Veldeman, Liv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814154/
https://www.ncbi.nlm.nih.gov/pubmed/35115610
http://dx.doi.org/10.1038/s41598-022-05957-7
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author Deseyne, Pieter
Speleers, Bruno
Paelinck, Leen
De Gersem, Werner
De Neve, Wilfried
Schoepen, Max
Van Greveling, Annick
Van Hulle, Hans
Vakaet, Vincent
Post, Giselle
Monten, Chris
Depypere, Herman
Veldeman, Liv
author_facet Deseyne, Pieter
Speleers, Bruno
Paelinck, Leen
De Gersem, Werner
De Neve, Wilfried
Schoepen, Max
Van Greveling, Annick
Van Hulle, Hans
Vakaet, Vincent
Post, Giselle
Monten, Chris
Depypere, Herman
Veldeman, Liv
author_sort Deseyne, Pieter
collection PubMed
description In whole breast and regional nodal irradiation (WB + RNI), breathhold increases organ at risk (OAR) sparing. WB + RNI is usually performed in supine position, because positioning materials obstruct beam paths in prone position. Recent advancements allow prone WB + RNI (pWB + RNI) with increased sparing of OARs compared to supine WB + RNI. We evaluate positional and dosimetrical impact of repeated breathhold (RBH) and failure to breathhold (FTBH) in pWB + RNI. Twenty left-sided breast cancer patients were scanned twice in breathhold (baseline and RBH) and once free breathing (i.e. FTBH). Positional impact was evaluated using overlap index (OI) and Dice similarity coefficient (DSC). Dosimetrical impact was assessed by beam transposition from the baseline plan. Mean OI and DSC ranges were 0.01–0.98 and 0.01–0.92 for FTBH, and 0.73–1 and 0.69–1 for RBH. Dosimetric impact of RBH was negligible. FTBH significantly decreased minimal dose to CTV WBI, level II and the internal mammary nodes, with adequate mean doses. FTBH significantly increased heart, LAD, left lung and esophagus dose. OI and DSC for RBH and FTBH show reproducible large ROI positions. Small ROIs show poor overlap. FTBH maintained adequate target coverage but increased heart, LAD, ipsilateral lung and esophagus dose. RBH is a robust technique in pWB + RNI. (Clinicaltrials.gov: NCT05179161, registered 05/01/2022).
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spelling pubmed-88141542022-02-07 Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position Deseyne, Pieter Speleers, Bruno Paelinck, Leen De Gersem, Werner De Neve, Wilfried Schoepen, Max Van Greveling, Annick Van Hulle, Hans Vakaet, Vincent Post, Giselle Monten, Chris Depypere, Herman Veldeman, Liv Sci Rep Article In whole breast and regional nodal irradiation (WB + RNI), breathhold increases organ at risk (OAR) sparing. WB + RNI is usually performed in supine position, because positioning materials obstruct beam paths in prone position. Recent advancements allow prone WB + RNI (pWB + RNI) with increased sparing of OARs compared to supine WB + RNI. We evaluate positional and dosimetrical impact of repeated breathhold (RBH) and failure to breathhold (FTBH) in pWB + RNI. Twenty left-sided breast cancer patients were scanned twice in breathhold (baseline and RBH) and once free breathing (i.e. FTBH). Positional impact was evaluated using overlap index (OI) and Dice similarity coefficient (DSC). Dosimetrical impact was assessed by beam transposition from the baseline plan. Mean OI and DSC ranges were 0.01–0.98 and 0.01–0.92 for FTBH, and 0.73–1 and 0.69–1 for RBH. Dosimetric impact of RBH was negligible. FTBH significantly decreased minimal dose to CTV WBI, level II and the internal mammary nodes, with adequate mean doses. FTBH significantly increased heart, LAD, left lung and esophagus dose. OI and DSC for RBH and FTBH show reproducible large ROI positions. Small ROIs show poor overlap. FTBH maintained adequate target coverage but increased heart, LAD, ipsilateral lung and esophagus dose. RBH is a robust technique in pWB + RNI. (Clinicaltrials.gov: NCT05179161, registered 05/01/2022). Nature Publishing Group UK 2022-02-03 /pmc/articles/PMC8814154/ /pubmed/35115610 http://dx.doi.org/10.1038/s41598-022-05957-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Deseyne, Pieter
Speleers, Bruno
Paelinck, Leen
De Gersem, Werner
De Neve, Wilfried
Schoepen, Max
Van Greveling, Annick
Van Hulle, Hans
Vakaet, Vincent
Post, Giselle
Monten, Chris
Depypere, Herman
Veldeman, Liv
Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position
title Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position
title_full Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position
title_fullStr Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position
title_full_unstemmed Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position
title_short Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position
title_sort reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814154/
https://www.ncbi.nlm.nih.gov/pubmed/35115610
http://dx.doi.org/10.1038/s41598-022-05957-7
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