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Alternation of the Autonomic Nervous System Is Associated With Pulmonary Sequelae in Patients With COVID-19 After Six Months of Discharge

Previous studies suggest that autonomic dysfunction is associated with disease severity in acute phase in patients with coronavirus disease 2019 (COVID-19). However, the association between autonomic dysfunction and pulmonary sequelae in patients with COVID-19 is unknown. We conducted a prospective...

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Autores principales: Bai, Tao, Zhou, Dan, Yushanjiang, Feierkaiti, Wang, Dongke, Zhang, Dongmei, Liu, Xinghuang, Song, Jun, Zhang, Jianchu, Hou, Xiaohua, Ma, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814436/
https://www.ncbi.nlm.nih.gov/pubmed/35126184
http://dx.doi.org/10.3389/fphys.2021.805925
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author Bai, Tao
Zhou, Dan
Yushanjiang, Feierkaiti
Wang, Dongke
Zhang, Dongmei
Liu, Xinghuang
Song, Jun
Zhang, Jianchu
Hou, Xiaohua
Ma, Yanling
author_facet Bai, Tao
Zhou, Dan
Yushanjiang, Feierkaiti
Wang, Dongke
Zhang, Dongmei
Liu, Xinghuang
Song, Jun
Zhang, Jianchu
Hou, Xiaohua
Ma, Yanling
author_sort Bai, Tao
collection PubMed
description Previous studies suggest that autonomic dysfunction is associated with disease severity in acute phase in patients with coronavirus disease 2019 (COVID-19). However, the association between autonomic dysfunction and pulmonary sequelae in patients with COVID-19 is unknown. We conducted a prospective study to investigate the association between autonomic dysfunction and pulmonary sequelae in patients with COVID-19 discharged for 6 months. We included 40 eligible participants and collected the following indicators: heart rate variability (HRV), pulmonary function tests (PFTs), lung X-ray computed tomography (CT), routine blood parameters, liver function parameters, and lymphocyte subsets. We found that at 6 months post-discharge, HRV still had a tight correlation with pulmonary fibrosis. There was a significant difference in HRV between patients with and without diffusion dysfunction, but HRV did not differ between patients with or without ventilatory dysfunction. Diffusion dysfunction and pulmonary fibrosis were tightly associated, and HRV index changes in patients with diffusion dysfunction had the same trend as that of patients with pulmonary fibrosis. They had a lower standard deviation of NN intervals (SDNN), the standard deviation of the average NN intervals (SDANN), and the triangular index, but a higher ratio between LF and HF power (LF/HF). In addition, WBC, neutrophils, and CD4/CD8 were correlated with pulmonary fibrosis and HRV. We concluded that autonomic dysfunction is closely associated with pulmonary fibrosis and diffusion dysfunction, and immune mechanisms may potentially contribute to this process.
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spelling pubmed-88144362022-02-05 Alternation of the Autonomic Nervous System Is Associated With Pulmonary Sequelae in Patients With COVID-19 After Six Months of Discharge Bai, Tao Zhou, Dan Yushanjiang, Feierkaiti Wang, Dongke Zhang, Dongmei Liu, Xinghuang Song, Jun Zhang, Jianchu Hou, Xiaohua Ma, Yanling Front Physiol Physiology Previous studies suggest that autonomic dysfunction is associated with disease severity in acute phase in patients with coronavirus disease 2019 (COVID-19). However, the association between autonomic dysfunction and pulmonary sequelae in patients with COVID-19 is unknown. We conducted a prospective study to investigate the association between autonomic dysfunction and pulmonary sequelae in patients with COVID-19 discharged for 6 months. We included 40 eligible participants and collected the following indicators: heart rate variability (HRV), pulmonary function tests (PFTs), lung X-ray computed tomography (CT), routine blood parameters, liver function parameters, and lymphocyte subsets. We found that at 6 months post-discharge, HRV still had a tight correlation with pulmonary fibrosis. There was a significant difference in HRV between patients with and without diffusion dysfunction, but HRV did not differ between patients with or without ventilatory dysfunction. Diffusion dysfunction and pulmonary fibrosis were tightly associated, and HRV index changes in patients with diffusion dysfunction had the same trend as that of patients with pulmonary fibrosis. They had a lower standard deviation of NN intervals (SDNN), the standard deviation of the average NN intervals (SDANN), and the triangular index, but a higher ratio between LF and HF power (LF/HF). In addition, WBC, neutrophils, and CD4/CD8 were correlated with pulmonary fibrosis and HRV. We concluded that autonomic dysfunction is closely associated with pulmonary fibrosis and diffusion dysfunction, and immune mechanisms may potentially contribute to this process. Frontiers Media S.A. 2022-01-21 /pmc/articles/PMC8814436/ /pubmed/35126184 http://dx.doi.org/10.3389/fphys.2021.805925 Text en Copyright © 2022 Bai, Zhou, Yushanjiang, Wang, Zhang, Liu, Song, Zhang, Hou and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Bai, Tao
Zhou, Dan
Yushanjiang, Feierkaiti
Wang, Dongke
Zhang, Dongmei
Liu, Xinghuang
Song, Jun
Zhang, Jianchu
Hou, Xiaohua
Ma, Yanling
Alternation of the Autonomic Nervous System Is Associated With Pulmonary Sequelae in Patients With COVID-19 After Six Months of Discharge
title Alternation of the Autonomic Nervous System Is Associated With Pulmonary Sequelae in Patients With COVID-19 After Six Months of Discharge
title_full Alternation of the Autonomic Nervous System Is Associated With Pulmonary Sequelae in Patients With COVID-19 After Six Months of Discharge
title_fullStr Alternation of the Autonomic Nervous System Is Associated With Pulmonary Sequelae in Patients With COVID-19 After Six Months of Discharge
title_full_unstemmed Alternation of the Autonomic Nervous System Is Associated With Pulmonary Sequelae in Patients With COVID-19 After Six Months of Discharge
title_short Alternation of the Autonomic Nervous System Is Associated With Pulmonary Sequelae in Patients With COVID-19 After Six Months of Discharge
title_sort alternation of the autonomic nervous system is associated with pulmonary sequelae in patients with covid-19 after six months of discharge
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814436/
https://www.ncbi.nlm.nih.gov/pubmed/35126184
http://dx.doi.org/10.3389/fphys.2021.805925
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