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Serum Cortisol Is Associated With Cerebral Small Vessel Disease-Related Brain Changes and Cognitive Impairment

OBJECTIVE: To evaluate the relationship between serum cortisol, cerebral small vessel disease (CSVD) neuroimaging markers, and cognitive performance. METHODS: We recruited patients over 50 years old who attended our hospital for physical examination between November 2020 and July 2021. All participa...

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Autores principales: Qiu, Qianwen, Zhou, Xirui, Wu, Lingshan, Zhang, Yi, Yu, Zhiyuan, Wang, Minghuan, Huang, Hao, Luo, Xiang, Pan, Dengji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814515/
https://www.ncbi.nlm.nih.gov/pubmed/35126094
http://dx.doi.org/10.3389/fnagi.2021.809684
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author Qiu, Qianwen
Zhou, Xirui
Wu, Lingshan
Zhang, Yi
Yu, Zhiyuan
Wang, Minghuan
Huang, Hao
Luo, Xiang
Pan, Dengji
author_facet Qiu, Qianwen
Zhou, Xirui
Wu, Lingshan
Zhang, Yi
Yu, Zhiyuan
Wang, Minghuan
Huang, Hao
Luo, Xiang
Pan, Dengji
author_sort Qiu, Qianwen
collection PubMed
description OBJECTIVE: To evaluate the relationship between serum cortisol, cerebral small vessel disease (CSVD) neuroimaging markers, and cognitive performance. METHODS: We recruited patients over 50 years old who attended our hospital for physical examination between November 2020 and July 2021. All participants were subject to brain magnetic resonance imaging (MRI), serum cortisol examination, and the Montreal cognitive function assessment (MoCA). On brain MRI, we scored the presence of each marker of CSVD, including white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVS). One point was awarded for the presence of each marker, producing a score between 0 and 4. RESULTS: In total, 158 participants were included in this study with a mean age of 60.5 (56.0–66.3) years; 55.1% were male. In the multivariable analyses, serum cortisol level was an independent predictor of WMH severity, the presence of lacunes/CMBs, moderate-severe EPVS and total CSVD burden after adjusting for confounding factors. Serum cortisol level had positive associations with periventricular/deep Fazekas score, burdens of lacunes/CMBs, moderate-severe EPVS, and total CSVD burden in dose-dependent manner, and was an independent predictor of cognitive impairment. Furthermore, the results of the receiver operating characteristic (ROC) curve analysis revealed an area under curve (AUC) of 0.745 with 64.1% sensitivity and 82.5% specificity, and an AUC of 0.705 with 52.1% sensitivity and 85.5 specificity of cortisol in detecting patients with high CSVD burden and MCI, respectively. CONCLUSIONS: Serum cortisol level is independently associated with each CSVD MRI markers, total CSVD burden and cognitive impairment. These findings provide clues for pathological mechanisms and suggest serum cortisol as a promising biomarker associated with CSVD.
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spelling pubmed-88145152022-02-05 Serum Cortisol Is Associated With Cerebral Small Vessel Disease-Related Brain Changes and Cognitive Impairment Qiu, Qianwen Zhou, Xirui Wu, Lingshan Zhang, Yi Yu, Zhiyuan Wang, Minghuan Huang, Hao Luo, Xiang Pan, Dengji Front Aging Neurosci Aging Neuroscience OBJECTIVE: To evaluate the relationship between serum cortisol, cerebral small vessel disease (CSVD) neuroimaging markers, and cognitive performance. METHODS: We recruited patients over 50 years old who attended our hospital for physical examination between November 2020 and July 2021. All participants were subject to brain magnetic resonance imaging (MRI), serum cortisol examination, and the Montreal cognitive function assessment (MoCA). On brain MRI, we scored the presence of each marker of CSVD, including white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVS). One point was awarded for the presence of each marker, producing a score between 0 and 4. RESULTS: In total, 158 participants were included in this study with a mean age of 60.5 (56.0–66.3) years; 55.1% were male. In the multivariable analyses, serum cortisol level was an independent predictor of WMH severity, the presence of lacunes/CMBs, moderate-severe EPVS and total CSVD burden after adjusting for confounding factors. Serum cortisol level had positive associations with periventricular/deep Fazekas score, burdens of lacunes/CMBs, moderate-severe EPVS, and total CSVD burden in dose-dependent manner, and was an independent predictor of cognitive impairment. Furthermore, the results of the receiver operating characteristic (ROC) curve analysis revealed an area under curve (AUC) of 0.745 with 64.1% sensitivity and 82.5% specificity, and an AUC of 0.705 with 52.1% sensitivity and 85.5 specificity of cortisol in detecting patients with high CSVD burden and MCI, respectively. CONCLUSIONS: Serum cortisol level is independently associated with each CSVD MRI markers, total CSVD burden and cognitive impairment. These findings provide clues for pathological mechanisms and suggest serum cortisol as a promising biomarker associated with CSVD. Frontiers Media S.A. 2022-01-21 /pmc/articles/PMC8814515/ /pubmed/35126094 http://dx.doi.org/10.3389/fnagi.2021.809684 Text en Copyright © 2022 Qiu, Zhou, Wu, Zhang, Yu, Wang, Huang, Luo and Pan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Qiu, Qianwen
Zhou, Xirui
Wu, Lingshan
Zhang, Yi
Yu, Zhiyuan
Wang, Minghuan
Huang, Hao
Luo, Xiang
Pan, Dengji
Serum Cortisol Is Associated With Cerebral Small Vessel Disease-Related Brain Changes and Cognitive Impairment
title Serum Cortisol Is Associated With Cerebral Small Vessel Disease-Related Brain Changes and Cognitive Impairment
title_full Serum Cortisol Is Associated With Cerebral Small Vessel Disease-Related Brain Changes and Cognitive Impairment
title_fullStr Serum Cortisol Is Associated With Cerebral Small Vessel Disease-Related Brain Changes and Cognitive Impairment
title_full_unstemmed Serum Cortisol Is Associated With Cerebral Small Vessel Disease-Related Brain Changes and Cognitive Impairment
title_short Serum Cortisol Is Associated With Cerebral Small Vessel Disease-Related Brain Changes and Cognitive Impairment
title_sort serum cortisol is associated with cerebral small vessel disease-related brain changes and cognitive impairment
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814515/
https://www.ncbi.nlm.nih.gov/pubmed/35126094
http://dx.doi.org/10.3389/fnagi.2021.809684
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