An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination: A Case Report

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scar tissue formation. An acute exacerbation of IPF (AE-IPF) is a clinically significant respiratory decompensation that accounts for a significant proportion of IPF-related morbidity and mortality....

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Detalles Bibliográficos
Autores principales: Ghincea, Alexander, Ryu, Changwan, Herzog, Erica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc under license from the American College of Chest Physicians. 2022
Materias:
Novel Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814523/
https://www.ncbi.nlm.nih.gov/pubmed/35131075
http://dx.doi.org/10.1016/j.chest.2021.07.2160
Descripción
Sumario:Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scar tissue formation. An acute exacerbation of IPF (AE-IPF) is a clinically significant respiratory decompensation that accounts for a significant proportion of IPF-related morbidity and mortality. AE-IPF can be idiopathic or associated with pulmonary embolism, infection, aspiration, surgery, and drug toxicity. In this novel case report, we describe a potential association between AE-IPF and BNT162b2 mRNA COVID-19 vaccination that was successfully treated with a short course of glucocorticoids. While our aim is to raise awareness for this yet-to-be-described adverse event, immunization against vaccine-preventable disease remains widely recommended in vulnerable patients with chronic lung disease such as IPF.

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